Physical activity and the risk of breast cancer among Nigerian women |
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| Affiliation: | 1. Department of Public Health, Fculty of Health Sciences, National Open University of Nigeria, Abuja, Nigeria;2. Population Health Sciences Institute, Newcastle University, United Kingdom;3. Department of Radiation Biology, Radiotherapy & Radiodiagnosis, College of Medicine, University of Lagos/Lagos University Teaching Hospital, Lagos, Nigeria;4. Department of Radiotherapy and Oncology, National Hospital, Abuja, Nigeria;1. Departamento de Medicina Legal, Etica Medica, Medicina Social e do Trabalho, Instituto Oscar Freire, LIM-40, Faculdade de Medicina da Universidade de Sao Paulo (FMUSP), Av Dr. Arnaldo, 455, Sao Paulo, Brazil;2. Centro de Investigação Translacional em Oncologia, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Av Dr. Arnaldo, 251, Sao Paulo, Brazil;3. Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia, Hospital Heliopolis, R Cônego Xavier, 276, Sao Paulo, Brazil;1. HCA Florida Brandon Hospital Department of Internal Medicine, 119 Oakfield Drive, Brandon, FL 33511, USA;2. University of Kansas School of Medicine Department of Population Health, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA;3. University of Kansas Cancer Center, 4000 Cambridge Street, Kansas City, KS 66160, USA;1. Department of Urology, New York University Grossman School of Medicine, New York, NY, United States;2. Department of Urology, SUNY Downstate Health Sciences Campus, Brooklyn, NY, United States;3. Department of Population Health, New York University Grossman School of Medicine, New York, NY, United States;4. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States;5. Department of Urology, University of North Carolina, Chapel Hill, NC, United States;6. VA NY Harbor Healthcare System, United States;7. Department of Surgery, Urology Service; Memorial Sloan Kettering Cancer Center;1. Department of Urology, University of North Carolina, Chapel Hill, NC, USA;2. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA;3. Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA;4. Office of Behavioral Health, Health + Hospitals, New York, NY, USA;5. Section on Tobacco, Alcohol and Drug Use, Department of Population Health, New York University School of Medicine, New York, NY, USA;6. Department of Urology, New York University, New York, NY, USA;7. Department of Population Health, New York University School of Medicine, New York, NY, USA;1. College of Life Sciences, Hebei University, Baoding 071002, China;2. Department of Cancer Epidemiology, National Cancer Center/ National Clinical Research Center for Cancer/ Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China;3. Center for Global Health, School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China;4. Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20850, USA;5. Department of Clinical Nutrition, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing 400042, China;6. College of Osteopathic Medicine of the Pacific, Western University of Health Science, Pomona, CA 91766, USA |
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| Abstract: | BackgroundAlthough physical activity has been associated with a reduced risk of breast cancer risk in high income countries (HIC), its role has not been widely studied in sub-Saharan Africa. Our aim was to investigate the association between physical activity (PA) and the risk of breast cancer in Nigeria.MethodsWe conducted a hospital-based case-control study involving participants from five hospitals in Lagos and Abuja. Women were interviewed in-person between October 2016 and May 2017 using a semi-structured questionnaire. Total PA was estimated by summing occupational, household, transport and leisure PA scores. PA was summarised as metabolic equivalents (MET) hours per week (MET-hr/wk). The putative association between breast cancer incidence and PA was analysed using multivariable logistic regression.Results379 histologically confirmed breast cancer cases and 403 controls took part. Compared to women in the lowest categories, women in the upper middle category of total PA(adjusted OR-AOR 0.44, 95% CI: 0.27, 0.78),uppermost categories of total non-vigorous PA (AOR 0.26, 95%CI:0.09,0.75), household PA(AOR 0.0.38, 95% CI: 0.20, 0.71) and occupational PA (AOR 0.64, 95% 0.40, 1.02) had a reduced risk of breast cancer following adjustment for relevant confounders. Transport and leisure PA were not significantly associated with a reduced risk of breast cancer.ConclusionThe total effect of various PA related to regular activities of Nigerian women was associated with a reduced risk of breast cancer. PA especially at household and occupational environments should be promoted as part of breast cancer prevention strategy in Nigeria. |
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| Keywords: | Physical activity Breast cancer Risk factor Women sub-saharan Africa Nigeria |
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