Two new flavonol derivatives from the whole plants of Centella asiatica and their cytotoxic activities |
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| Affiliation: | 1. Pharmacy Department, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai 201800, China;2. College of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430070, China;3. Department of Pharmaceutical Science, Medical College, Hunan Normal University, Changsha 410013, China;1. Escuela de Química, Universidad Autónoma de Santo Domingo (UASD), Facultad de Ciencias, Ciudad Universitaria, Santo Domingo, D.N., Dominican Republic;2. Instituto de Química, Universidad Autónoma de Santo Domingo (UASD), Facultad de Ciencias, Ciudad Universitaria, Santo Domingo, D.N., Dominican Republic;3. BioLab, Instituto Universitario de Bio-Orgánica Antonio González (IUBO-AG), Universidad de La Laguna, 38206 La Laguna, Spain;4. Biointerfaces Institute, McMaster University, Engineering Technology Building, Room 413, 1280 Main Street West, Hamilton, ON L8S 0A3, Canada;1. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin, 541006, China;2. College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, 530200, China;1. Centro de Investigaciones en Productos Naturales, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;2. Centro de Investigación en Biología Celular y Molecular, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;3. Centro de Electroquímica y Energía Química, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;4. Escuela de Química, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;1. College of Medicine, Henan Polytechnic University, Jiaozuo, 454000, PR China;2. Beijing Bencaoyuan Pharmaceutical Co., Ltd, Beijing, 102629, PR China;1. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People’s Republic of China;2. Analytical & Measuring Center of School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People’s Republic of China |
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| Abstract: | Centella asiatica is well known as an important medicinal plant because of its various pharmacological effects. However, most investigations on C. asiatica focused on the pharmacological activity of its extract or asiatic acid. In the present work, we aimed to explore the bioactive compounds of the whole plants of C. asiatica. As a result, seven compounds including two new flavonol derivates named 4′-hydroxyl-7-methoxyl-6-prenyl-3-O-trans-p-coumaroyl-flavonol (1) and (2R,3R,2″S)-3-furanoyl-brosimacutin E (2), and five known compounds (3-7) were isolated. Their chemical structures were elucidated on the basis of spectroscopic analyses. All the isolates were evaluated for in vitro cytotoxic effects on four human cancer cells including A549, HepG2, SGC-7901 and MCF-7. Among them, compounds 1 and 2 exhibited higher cytotoxic activities on HepG2 and SGC-7901 cells compared with 3-7. And compound 2 showed potential cytotoxic activities on HepG2 and SGC-7901 cells with IC50 values of 4.52 and 7.03 μM, respectively. |
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| Keywords: | Apiaceae Flavonol derivates Cytotoxic activity |
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