Promoting remyelination: A case study in regenerative medicine |
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| Institution: | 1. Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics & Coimbra Institute for Clinical and Biomedical Research (iCBR), University of Coimbra, Celas, Coimbra 3000-548, Portugal;2. Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal;3. Clinical Academic Center of Coimbra (CACC), Coimbra, Portugal;4. Center for Child Development – Neuropediatrics Unit, Hospital Pediátrico, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal;5. Pharmacy/Biomedical Laboratory Sciences, Polytechnic Institute of Coimbra, ESTESC-Coimbra Health School, Coimbra, Portugal;6. Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), University of Coimbra, Coimbra, Portugal;7. Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra, Coimbra, Portugal |
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| Abstract: | Therapeutics that modulate regenerative mechanisms by targeting the activity of endogenous (adult) stem cell populations have the potential to revolutionize medicine. In many human disease states, capacity to repair damaged tissue underlies progressive decline and disease progression. Recent insights derived from efforts aimed at promoting remyelination for the treatment of multiple sclerosis (MS) highlight the importance of considering the limiting factors and underlying mechanisms associated with all aspects of disease onset, progression and recovery, during both the discovery and clinical stages of developing a regenerative medicine. This perspective presents general considerations for the development of regenerative therapies, using remyelination as a case study. |
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| Keywords: | Remyelination Regenerative medicine Oligodendrocyte Phenotypic screening |
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