Pre-diagnostic circulating p53 autoantibodies and subsequent lung cancer risk in low-income African and European Americans |
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| Institution: | 1. Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, 37203, USA;2. Division of Infections and Cancer Epidemiology, Infection, Inflammation and Cancer Program, German Cancer Research Center (DFKZ), Heidelberg, Germany;1. Research Unit for General Practice, Aarhus, Bartholins Alle 2, 8000 Aarhus C, Denmark;2. Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 82, 8200 Aarhus C, Denmark;1. Student Research Committee, School of Medical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran;2. Medical Oncologist-Hematologist, Internal Medicine Department, Talaghani Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran;3. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran;1. Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, United States;2. Section of Hematology/Oncology, Department of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, United States;3. Center for Applied Social Research, College of Arts and Sciences, University of Oklahoma, Norman, OK, 73072, United States;1. Ontario Health (Cancer Care Ontario), 525 University Ave, Toronto, Ontario, Canada;2. Epidemiology & Biostatistics, Western University, London, Ontario, Canada;3. Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;4. Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada;5. Division of Medical Oncology & Hematology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada;6. Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada;7. Division of Thoracic Surgery, Toronto General Hospital, Toronto, Ontario, Canada;1. Endocrine Department, Zibo Central Hospital, Zibo 255000, Shandong, China;2. Department of Pathology, Zibo Central Hospital, Zibo 255000, Shandong, China;1. Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, China;2. Hotan District People’s Hospital, Hotan, Xinjiang 848000, China |
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| Abstract: | IntroductionMutations of the TP53 gene lead to the production of autoantibodies against p53, a major tumor suppressor protein. Although studies have indicated the association of p53 autoantibodies with human cancers, epidemiologic evidence on lung cancer is still lacking.MethodsIn this nested case-control study conducted within the Southern Community Cohort Study, we investigated the association of circulating p53 autoantibodies with the subsequent risk of developing lung cancer. Using blood samples collected prior to any cancer diagnosis from 295 cases and their individually matched controls, seroreactivity to p53 was assessed by fluorescent bead-based multiplex serology. Conditional logistic regression models were used to estimate odds ratios (OR) and 95 % confidence intervals (CI) for lung cancer risk associated with p53 autoantibodies.ResultsAfter adjustment for potential confounders, p53 seropositivity was significantly associated with an increased risk of lung cancer (OR=2.98, 95 % CI: 1.10–8.06) among African Americans, but not among European Americans (OR=1.21, 95 % CI: 0.24–6.15). The positive associations were restricted to men (OR=4.59, 95 % CI: 1.30–16.16) and participants with a short interval (≤ 4 years) from blood collection to diagnosis (OR=4.30, 95 % CI: 1.33–13.89).ConclusionOur findings add to the evidence supporting p53 autoantibodies as a biomarker of lung cancer. |
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| Keywords: | Lung cancer P53 Autoantibodies African Americans Low-Income Populations Southern Community Cohort Study SCCS"} {"#name":"keyword" "$":{"id":"key0040"} "$$":[{"#name":"text" "_":"Southern Community Cohort Study |
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