Two new ent-kaurane diterpenoids from the leaves of Sphagneticola trilobata |
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| Institution: | 1. State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources/Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China;2. Shaanxi Academy of Traditional Chinese Medicine, Xi''an 710003, China;3. Guangdong Provincial Key Laboratory of Silviculture, Protection and Utilization, Guangdong Academy of Forestry, Guangzhou 510520, China;1. School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, PR China;2. National Demonstration Center for Experimental Ethnopharmacology Education, South-Central Minzu University, Wuhan 430074, PR China;1. College of Biology and Environmental Science, Jishou University, Jishou 416000, China;2. School of Pharmaceutical Sciences, Jishou University, Jishou 416000, China;3. School of Medicine, Jishou University, Jishou 416000, China;4. Key Laboratory of Tujia Medicine Inheritance and Innovation, National Ethnic Affairs Commission of the People''s Republic of China, Jishou University, Jishou 416000, China;5. National Engineering Technology Research Center for Modernization of Traditional Chinese Medicine, Jishou University, Zhuhai 519085, China;1. The State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China;2. University of Chinese Academy of Sciences, Beijing 100039, China;1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China;2. University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China;3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210029, PR China;1. College of Life Sciences, Yunnan University, Kunming, Yunnan 650091, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;3. International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China;4. An Shun City People’s Hospital, Anshun 561000, China;5. Yunnan University of Traditional Chinese Medicine, Yunnan 650500, China;6. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China;1. Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China;2. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), No 28789 Jingshi Dong Road, Jinan 250103, China;3. Shaanxi Key Laboratory of Phytochemistry, Baoji 721013, Shaanxi, China |
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| Abstract: | Two new ent-kaurane diterpenoids, namely 3α,16α-dihydroxy-ent-kauran-19-oic acid (1) and 3α,9β-dihydroxy-ent-kauran-19-oic acid (2), together with eight known compounds were isolated and identified from the leaves of Sphagneticola trilobata. Their structures were elucidated on the basis of extensive spectroscopic analysis including 1D, 2D NMR and MS techniques. Known compounds 4, 5 and 8?10 were obtained from S. trilobata for the first time. These compounds were tested for their in vitro α-glucosidase inhibitory activity and their tyrosinase inhibitory potential. Compounds 2, 3 and 6 were found to show in vitro α-glucosidase inhibitory activity with IC50 values ranging from 0.398 to 0.476 mM, which were close or more potent than reference compound acarbose (IC50 0.410 mM). Compounds 2 and 6 were further revealed to show in vitro tyrosinase inhibitory activity (IC50 29.25 and 40.74 μM) but inferior to that of the positive control kojic acid (IC50 12.55 μM). |
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| Keywords: | tyrosinase inhibitory activity |
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