Quantitative imaging approaches to understanding biological processing of metal ions |
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| Affiliation: | 1. The Chemistry of Life Processes Institute, Northwestern University, Evanston, IL, USA;2. Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI, USA;3. Department of Chemistry, Michigan State University, East Lansing, MI, USA;4. Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA;5. Department of Chemistry, Northwestern University, Evanston, IL, USA;6. Elemental Health Institute, Michigan State University, East Lansing, MI, USA;1. Department of Chemistry, University of California, Berkeley, CA, 94720, USA;2. Department of Molecular & Cell Biology, University of California, Berkeley, CA, 94720, USA;3. Helen Wills Neuroscience Institute, University of California, Berkeley, CA, 94720, USA;1. Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA, 16802, USA;2. Department of Chemistry, The Pennsylvania State University, University Park, PA, 16802, USA;1. RNA Systems Biochemistry Laboratory, RIKEN Cluster for Pioneering Research, Wako, Saitama, 351-0198, Japan;2. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, 277-8561, Japan;1. Área Química Inorgánica, Facultad de Química, Universidad de la República, Montevideo 11800, Uruguay;2. Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA;3. Cell and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA;1. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, PR China;3. Chemistry and Chemical Engineering Guangdong Laboratory, Shantou, 515031, PR China;4. Spin-X Institute, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, PR China;5. Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials |
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| Abstract: | Faster, more sensitive, and higher resolution quantitative instrumentation are aiding a deeper understanding of how inorganic chemistry regulates key biological processes. Researchers can now image and quantify metals with subcellular resolution, leading to a vast array of new discoveries in organismal development, pathology, and disease. Metals have recently been implicated in several diseases such as Parkinson's, Alzheimers, ischemic stroke, and colorectal cancer that would not be possible without these advancements. In this review, instead of focusing on instrumentation we focus on recent applications of label-free elemental imaging and quantification and how these tools can lead to a broader understanding of metals role in systems biology and human pathology. |
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| Keywords: | Elemental imaging Metal imaging X-ray fluorescence microscopy Laser ablation inductively coupled mass spectrometry Metal physiology/pathology Predictive modeling XFM" },{" #name" :" keyword" ," $" :{" id" :" pc_9n1eVSwtbG" }," $$" :[{" #name" :" text" ," _" :" X-ray fluorescence microscopy LA-ICP-MS" },{" #name" :" keyword" ," $" :{" id" :" pc_LybPIIgALt" }," $$" :[{" #name" :" text" ," _" :" laser ablation inductively coupled plasma mass spectrometry AEM" },{" #name" :" keyword" ," $" :{" id" :" pc_suL3ZtgQmv" }," $$" :[{" #name" :" text" ," _" :" analytical electron microscopy nanoSIMS" },{" #name" :" keyword" ," $" :{" id" :" pc_QfJpDR1MXj" }," $$" :[{" #name" :" text" ," _" :" nanoscale secondary ion mass spectrometry STXM" },{" #name" :" keyword" ," $" :{" id" :" pc_4ylUu8H3Pw" }," $$" :[{" #name" :" text" ," _" :" scanning transmission X-ray microscopy |
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