Anti-inflammatory effects of two new stilbene-phenylpropanoid derivatives from Chamaecrista pumila |
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| Institution: | 1. Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hoankiem, Hanoi, Viet Nam;2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam;1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China;2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, PR China;3. Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China, Zhengzhou 450046, PR China;1. Xiangya School of Public Health, Central South University, Changsha 410083, PR China;2. Yunnan Comprehensive Health Supervision Center, Kunming 650032, PR China;3. School of Chinese Materia Medica &Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming 650500, PR China;1. Hunan Province Cooperative innovation Center for Molecular Target New Drug Study, the Key Laboratory of Environment and Critical Human Diseases Prevention of the Education Department of Hunan Province, Hengyang Medical School, University of South China, Hengyang 421001, China;2. College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China;3. South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;1. Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, District 5, Ho Chi Minh City, Viet Nam;2. Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam;3. Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam;4. Department of Biological Resources, Institute of Tropical Biology, VAST, 85 Tran Quoc Toan, Ho Chi Minh City, Viet Nam;1. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi 10072, Viet Nam;2. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10072, Viet Nam;3. Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10072, Viet Nam;4. Thai Nguyen University of Agriculture and Forestry, Quyet Thang, Thai Nguyen 24119, Viet Nam |
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| Abstract: | Two new stilbeno-phenylpropanoid compounds, given the trivial names chamaecristanols A and B (1 and 2), were isolated from the ethyl acetate-soluble partitions of separate methanol extracts of the aerial parts of Chamaecrista pumila (Lam.) K. Larsen. The structures of these compounds were determined on the basis of interpretation of their spectroscopic data and comparison with reported literature data. Their inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells were evaluated. Results showed that compounds 1 and 2 significantly inhibited NO production with IC50 values of 41.69 ± 1.34 and 32.14 ± 0.15 µM, respectively. |
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| Keywords: | Stilbeno-phenylpropanoid Chamaecristanols A-B Anti-inflammatory NO production activity |
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