New sesquiterpenoid and aliphatic glycoside from the roots of Datura metel L. |
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| Affiliation: | 1. Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education University of Chinese Medicine, Harbin 150040, PR China;2. Shandong Qingdao Hospital of Integrated Traditional and Western Medicine, PR China;1. College of Pharmacy, Fujian University of Traditional Chinese Medicine, No.1 Qiuyang Road, Fujian 350108, PR China;2. Department of Phytochemistry, School of Pharmacy, Naval Medical University, No. 325, Guohe Road, Shanghai 200433, PR China;3. School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, Yunnan, PR China;1. Instituto de Productos Naturales y Agrobiología, C.S.I.C., Avda. Astrofísico F. Sánchez 3, 38206-La Laguna, Tenerife, Canary Islands, Spain;2. Instituto Universitario de Bioorgánica “Antonio González”, Universidad de La Laguna, Tenerife, Spain;1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113, Thailand;2. National Biobank of Thailand, 114 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;3. School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, People’s Republic of China;1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;2. National Biobank of Thailand, 114 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;3. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People’s Republic of China;1. Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou 571199, PR China;2. Research Center for Drug Safety Evaluation of Hainan Province, Hainan Medical University, Haikou 571199, PR China;1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China;2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, PR China |
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| Abstract: | Three new compounds (1–3), were isolated from the 70%-EtOH extract of the roots of Datura metel L., along with thirty-six knowns (4–39). Their chemical structures were established based on extensive spectroscopic analyses, including HR-ESI-MS, 1D NMR, and 2D NMR as well as comparison with the data reported in the literature. Compounds 7, 8, 10, 12, 14, 15, 19-23, 27, 29, 31, and 34 were isolated from Solanaceae for the first time and compounds 4, 5, 9, 17, 18, and 26 were firstly isolated from the genus Datura. Moreover, compounds 1, 5, 9, 12, 13, 17, 23, 24, 28, 37, and 39 showed potential anti-inflammatory activities (IC50 <45 μM). |
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| Keywords: | Solanaceae RAW 264.7 Anti-inflammatory activity |
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