Dietary habits,nutrition and esophageal cancer: A case-control study on Kazakhs in Xinjiang |
| |
| Affiliation: | 1. Medical College, Jiaxing University, Jiaxing 314001, China;2. College of Public Health, Xinjiang Medical University, Urumqi 830054, China;3. Affiliated Hospital of Jiaxing University, Jiaxing 314001, China;4. Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi 830011, China;5. College of Public Health, Zhejiang Chinese Medical University, Hangzhou 310000, China;1. Research Unit for General Practice, Aarhus, Bartholins Alle 2, 8000 Aarhus C, Denmark;2. Department of Clinical Medicine, Aarhus University, Palle Juul-Jensens Boulevard 82, 8200 Aarhus C, Denmark;1. Department of Epidemiology, College of Public Health, University of Nebraska Medical Center, United States;2. Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, United States;1. Ontario Health (Cancer Care Ontario), 525 University Ave, Toronto, Ontario, Canada;2. Epidemiology & Biostatistics, Western University, London, Ontario, Canada;3. Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada;4. Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada;5. Division of Medical Oncology & Hematology, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada;6. Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada;7. Division of Thoracic Surgery, Toronto General Hospital, Toronto, Ontario, Canada;1. Ascension Saint Francis Hospital, 355 Ridge Ave, Evanston, IL 60202, USA;2. MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA;3. Texas Health Presbyterian Hospital Dallas, 8200 Walnut Hl Ln, Dallas, TX 75231, USA;1. Vaccine and Drug Evaluation Centre, Department of Community Health Sciences, University of Manitoba, 337-750 McDermot Avenue, Winnipeg, MB, Canada R3E 0T5;2. Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, Manitoba, Canada;3. Department of Hematology and Oncology, CancerCare Manitoba, Winnipeg, Manitoba, Canada;4. Department Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada;5. Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada;1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, South Korea;2. Department of Hematology and Medical Oncology, Kyung Hee University Hospital, School of Medicine, Kyun Hee University, Seoul, South Korea;3. Department of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, South Korea |
| |
| Abstract: | ObjectiveTo explore associations between dietary habits and esophageal epithelial cell carcinoma (ESCC) and provide a potential direction for exploring how different dietary habits and nutrient intake might affect ESCC development.Methods198 ESCC cases and 200 controls on Kazakhs were recruited in Xinjiang from 2010 to 2019 for a group-matched case-control study. The case group were recruited from the First Affiliated Hospital of Xinjiang Medical University and Affiliated Cancer Hospital of Xinjiang Medical University. The control population were recruited from two parts: hospital-based control and population-based control. The diagnosis was confirmed by histological examination. The food frequency questionnaire was used to investigate the dietary nutrients intake. Folic acid, vitamin B12, and DNA-methyltransferase 1(DNMT1) levels were measured in serum samples obtained from cases and controls.ResultsThe cholesterol intake of ESCC group was significantly higher than that of the control group while the intakes of protein, thiamin, riboflavin, folic acid, vitamin A, B6, C and E were significantly lower than the control group. Factors including lacking fresh vegetables and fruits, low educational level, low income, alcohol drinking, eating solid and dry food and smoked meat, dieting irregularly, salty taste preference, low serum folic acid level and high serum DNMT1 level were associated with increased risk of ESCC in Kazakhs.ConclusionDietary habits and nutrient intake were associated with increased risk of ESCC in Kazakhs that may provide a potential direction for further studies. |
| |
| Keywords: | Esophageal cancer Folic acid VitB12 DNMT1 Kazakh nationality |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
