A dinorcassane-type diterpene and a steroidal saponin from Distemonanthus benthamianus Baill. (Caesalpiniaceae) |
| |
| Affiliation: | 1. State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China;2. Guangdong Zhongsheng Pharmaceutical Co Ltd, Dongguan 440100, Guangdong, China;1. Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, University of Mainz, Staudinger Weg 5, 55128 Mainz, Germany;2. Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon;3. Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florianópolis 88040-900, SC, Brazil;1. Institute of Organic Chemistry, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany;2. Faculté des Sciences, Université de Kinshasa, B.P. 202, Kinshasa XI, People’s Republic of Congo;3. Institute of Pharmacy and Biochemistry, Department of Pharmaceutical Biology, University of Mainz, Staudinger Weg 5, D-55128 Mainz, Germany |
| |
| Abstract: | As part of our search for new bioactive compounds from medicinal plants growing in Cameroon, a previously unreported dinorcassane-type diterpenoid trivially named distemonanthin (1) and a new steroidal saponin, stigmasta-5,22-dien-3-O-β-D-glucopyranosyl-(1→3)-O-β-D-glucopyranoside (2) together with ten known compounds were isolated from the ethyl acetate and n-butanol soluble fractions of the methanol extract from the stem barks of Distemonanthus benthamianus. Their structures were established using 1D and 2D NMR spectroscopy, mass spectrometry and by comparison with spectroscopic data reported in the literature. The extract, fractions and some isolated compounds were screened for their antimicrobial properties and a significant inhibition was observed only for the n-butanol fraction against Candida albicans and Candida glabrata with MICs values of 32 and 64 µg/mL, respectively. |
| |
| Keywords: | Caesalpiniaceae Dinorcassane-type diterpenoid Saponins Antimicrobial activity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
