Two new diterpenoid quinones with lung protective activity from the roots of Salvia miltiorrhiza |
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| Affiliation: | 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China;2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, PR China;1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113, Thailand;2. National Biobank of Thailand, 114 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;3. School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, People’s Republic of China;1. Instituto de Productos Naturales y Agrobiología, C.S.I.C., Avda. Astrofísico F. Sánchez 3, 38206-La Laguna, Tenerife, Canary Islands, Spain;2. Instituto Universitario de Bioorgánica “Antonio González”, Universidad de La Laguna, Tenerife, Spain;1. Hunan Province Cooperative innovation Center for Molecular Target New Drug Study, the Key Laboratory of Environment and Critical Human Diseases Prevention of the Education Department of Hunan Province, Hengyang Medical School, University of South China, Hengyang 421001, China;2. College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China;3. South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China;1. Institute of Medical Research and Medicinal Plant Studies, P.O. Box 13033, Yaoundé, Cameroon;2. Bioorganic and Medicinal Chemistry Laboratory, Department of Organic Chemistry, Faculty of Sciences, University of Yaoundé I, P.O Box 812, Yaoundé, Cameroon;3. Department of Chemistry, Higher Teacher Training College Bambili, The University of Bamenda, P.O. Box 39, Bambili, Bamenda, Cameroon;4. Aix-Marseille Univ, CNRS, Centrale Marseille, FSCM, Spectropole, Campus de St Jérôme-Service 511, 13397 Marseille, France;5. Laboratory for Phytobiochemistry and Medicinal Plant Study, Antimicrobial and Biocontrol Agent Unit, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon;6. Aix-Marseille Univ, Avignon Université, CNRS, IRD, IMBE, FAC PHARM, Marseille, France;7. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;1. Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, District 5, Ho Chi Minh City, Viet Nam;2. Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam;3. Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam;4. Department of Biological Resources, Institute of Tropical Biology, VAST, 85 Tran Quoc Toan, Ho Chi Minh City, Viet Nam |
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| Abstract: | Two new diterpenoid quinones, salvianolactone acid J and K (1 and 2), as well as eight known compounds (3–10) were isolated from the roots of Salvia miltiorrhiza. Their structures were elucidated by comprehensive analysis. All compounds (1-10) were evaluated for their protective effects against the BEAS-2B cells injury induced by LPS in vitro and compounds 1, 3, and 4 showed significantly protective activity at the concentration of 10 μM. Besides, compounds 1, 3, and 4 ameliorated the nuclear transport of p-P65 in LPS-induced BEAS-2B cells. |
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| Keywords: | Lamiaceae Diterpenoid quinones Lung protective effect |
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