Insulin mimetic lanostane triterpenes from the cultivated mushroom Ganoderma orbiforme |
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| Affiliation: | 1. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, China;2. Key Laboratory of Regional Ecological Environment Analysis and Pollution Control of West Guangxi, School of Chemistry and Environment Engineering, Baise University, Baise 533000, China;1. Department of Food Science, Tunghai University, No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung, 40704, Taiwan;2. Department of Radiation Oncology, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Xitun District, Taichung, 40705, Taiwan;1. Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944401, Taiwan;2. National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan;3. Division of Dentistry, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813204, Taiwan;4. Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804201, Taiwan;5. Department of Nursing, Fooyin University, Kaohsiung 831301, Taiwan;6. Clinical Immunology Laboratory, Department of Medical Research, E-Da Hospital, Kaohsiung 824005, Taiwan;7. Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802301, Taiwan;8. Center for General Education, Cheng Shiu University, Kaohsiung 833301, Taiwan;9. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan;10. Institute of BioPharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung 804201, Taiwan;11. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan;12. Research Center for Chinese Herbal Medicine, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan;13. Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan;14. Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan;15. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404332, Taiwan;p. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807378, Taiwan;q. Ph.D. Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei 242062, Taiwan;1. Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 40402, Taiwan;2. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, 40402, Taiwan;3. Endemic Species Research Institute, Council of Agriculture, Nantou, 552203, Taiwan;4. School of Pharmacy, China Medical University, Taichung, 406040, Taiwan;5. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, 40447, Taiwan |
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| Abstract: | Two new lanostane triterpenes, ganorbifoins A and B (1-2), together with the known compound (25S,3′S)-(+)-12α-hydroxy-3α-(3′-hydroxy-4′-methoxycarbonyl-3′-methylbutiryloxy)-24-methyllanosta-824-(31)-dien-26-oic acid (3) were isolated from the cultivated fruiting bodies of Ganoderma orbiforme. The structures of isolates were determined by extensive analysis of NMR and HRESIMS. All compounds induced glucose uptake in zebrafish-based system at the concentration of 10 μM. And the best performing compound is ganorbifoin A. Compounds 2 and 3 exhibited an inhibitory effect on nitric oxide production in LPS-induced BV-2 microglia cells at the concentration of 20 μM. |
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| Keywords: | Lanostane triterpenes Insulin mimetics |
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