Constituents of Desmodium salicifolium (Poir.) DC (Fabaceae) with antifungal activity |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;2. Johannes Gutenberg University Mainz, Department of Chemistry, Duesbergweg 10-14, D-55128 Mainz, Germany;3. Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;4. School of Science and Technology, Chemistry Division, University of Camerino, via Madonna delle Carceri, 62032 Camerino, Italy;1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China;2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, PR China;3. Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China, Zhengzhou 450046, PR China;1. College of Pharmacy, Fujian University of Traditional Chinese Medicine, No.1 Qiuyang Road, Fujian 350108, PR China;2. Department of Phytochemistry, School of Pharmacy, Naval Medical University, No. 325, Guohe Road, Shanghai 200433, PR China;3. School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, Yunnan, PR China;1. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi 10072, Viet Nam;2. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10072, Viet Nam;3. Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi 10072, Viet Nam;4. Thai Nguyen University of Agriculture and Forestry, Quyet Thang, Thai Nguyen 24119, Viet Nam;1. Instituto de Productos Naturales y Agrobiología, C.S.I.C., Avda. Astrofísico F. Sánchez 3, 38206-La Laguna, Tenerife, Canary Islands, Spain;2. Instituto Universitario de Bioorgánica “Antonio González”, Universidad de La Laguna, Tenerife, Spain |
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| Abstract: | Phytochemical investigation of the roots of Desmodium salicifolium led to the isolation of two new compounds (Desmoflavanone A: 5,2',4'-trihydroxy-4'',4''-dimethyl-2H-dihydropyranoisoflavanone (1) and desmodioside A: (22R)-3β,22,23-trihydroxyolean-12-en-3-O-α- L-rhamnopyranosyl-(1→2)-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranoside (2)) together with nine known secondary metabolites including kaikasaponin III (3), spinosin (4), isovitexin (5), β-sitosterol 3-O-β-D-glucopyranoside (6), neorautenol (7), kaempferol (8), oleanolic acid (9), betulinic acid (10), and lupeol (11). The structures of these compounds were elucidated mainly by extensive spectroscopic analysis, particularly 1D and 2D NMR spectroscopy, electrospray ionization-mass spectrometry and by comparison of their spectroscopic data with those of related compounds reported in the literature. The methanolic extract, EtOAc and n-BuOH fractions as well as some isolated compounds were assessed for their antifungal activities against two fungi using microdilution method. The methanolic extract displayed weak activity against Candida albicans (MIC = 512 µg/mL). The EtOAc fraction also exhibited weak inhibitory effect with MIC of 256 µg/mL against Candida albicans and Candida glabrata. Compound 3 showed moderate effect against Candida glabrata with MIC value of 16 µg/mL while 1 was inactive against both fungi. |
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| Keywords: | Fabaceae Isoflavanone Triterpenoid saponin Antifungal activity |
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