Incidence of multiple myeloma in Kailuan cohort: A prospective community-based study in China |
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| Affiliation: | 1. Department of Hematology, Myeloma Research Center of Beijing, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China;2. Department of Hematology, Kailuan General Hospital, Tangshan, Hebei Province, China;3. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China;4. National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China;5. Department of Cardiology, Kailuan General Hospital, Tangshan, Hebei Province, China;1. Department of Urology, University of North Carolina, Chapel Hill, NC, USA;2. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA;3. Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC, USA;4. Office of Behavioral Health, Health + Hospitals, New York, NY, USA;5. Section on Tobacco, Alcohol and Drug Use, Department of Population Health, New York University School of Medicine, New York, NY, USA;6. Department of Urology, New York University, New York, NY, USA;7. Department of Population Health, New York University School of Medicine, New York, NY, USA;1. Department of Surgery and Endoscopy, Tenwek Hospital, Bomet, Kenya;2. Department of Surgery, Alpert Medical School of Brown University, Providence, RI, USA;3. Biostatistics Branch, Division of Cancer and Epidemiology, National Cancer Institute, Rockville, MD, USA;4. Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA;5. Department of Pathology, University of Nairobi, Nairobi, Kenya;6. Mayo Clinic, Rochester, MN, USA;1. Aurora Healthcare US Corp, 8 Electronics Ave., Danvers, MA 01923, USA;2. Department of OBGYN, Tufts Medical Center, 800 Washington St, Boston, MA 02111, USA;1. Department of Cancer Strategy, Cancer Control Center, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo-ku, Osaka City, Osaka Prefecture 541-8567, Japan;2. Inequalities in Cancer Outcome Network, Department of Non-communicable Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom |
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| Abstract: | BackgroundPrevious retrospective studies showed that the incidence and mortality rates for MM in China were lower than those in western countries. A large-scale prospective study on incidence and mortality rates of MM is still lacking.MethodsBased on the prospective Kailuan Cohort study in China, we included all patients with MM in Kailuan Cohort from June 1, 2008 to December 31, 2016. Using the numbers of diagnosed cases and deaths during the study period as the numerators and the corresponding observed person-years as the denominators respectively, we calculated crude incidence and mortality rates. The 95% confidence intervals for crude incidence rate and mortality rate were estimated base on Poisson distribution. Rates were standardized by direct standardization according to the China population in 2000 and Segi’ world standard population.ResultsA total of 22 members from Kailuan Cohort were first diagnosed with MM between 2008 and 2016. The calculated crude incidence rates were 2.8 (95% CI, 1.7–4.2) per 100,000 person-years for all participants. The standardized incidence rate was 0.9 per 100,000 person-years (95% CI, 0.5–2.1) when standardized by 2000 China population census data, and 1.0 per 100,000 person-years (95% CI, 0.6–1.8) when standardized by Segi’s world standard population (WSP). The calculated crude mortality rates were 2.3 (95% CI, 1.4–3.6) per 100,000 person-years. The mortality standardized by 2000 China population census data was 0.7 per 100,000 person-years (95% CI, 0.3–1.9), and 0.9 per 100,000 population (95% CI, 0.5–1.7) when standardized by Segi’s WSP. Both incidence and mortality for males were higher than that for females almost in all age groups. Both rates increased steadily with age.ConclusionIn this community-based prospective cohort study, we found that the incidence of MM in China was far lower than that in American and Europe. |
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| Keywords: | Multiple myeloma Incidence Mortality China |
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