Serial passage in resistant sheep drives the infectivity and fitness of Teladorsagia circumcincta in susceptible lambs: Experimental evidence |
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| Affiliation: | 1. INRAE, UMR 1282 Infectiologie et Santé Publique, F-37380 Nouzilly, France;2. Université de Tours, UMR 1282 Infectiologie et Santé Publique, F-37000 Tours, France;3. Scotland''s Rural College (SRUC), Animal and Veterinary Sciences, Roslin Institute Building, Midlothian EH25 9RG, UK;4. Facultad de Ciencias Veterinarias, Producción animal, Universidad Nacional de La Pampa, Calle 5 esq. 116 S/N, General Pico, Argentina;1. Posgrado en Ciencias Biológicas, Instituto de Biología, Universidad Nacional Autónoma de México, s/n, Ciudad Universitaria, Coyoacán, Ciudad de México C.P. 04510, Mexico;2. Instituto de Biología, Universidad Nacional Autónoma de México, Tercer circuito exterior s/n, Ciudad Universitaria, Coyoacán, Ciudad de México C.P. 04510, Mexico;1. Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan;2. ISGlobal, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain;3. Germans Trias i Pujol Health Research Institute (IGTP), Badalona (Barcelona), Spain;4. Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia;1. Tropical Infectious Diseases Research Centre (TIDRC), University of Abomey-Calavi, 01BP 526, Cotonou, Benin;2. Fondation Pour la Recherche Scientifique (FORS), ISBA, BP 88, Cotonou, Bénin;3. Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK;4. Institut Régional de Santé Publique/Université d''Abomey-Calavi, BP 384 Ouidah, Bénin;5. Department of Parasitology and Medical Entomology, Centre for Research in Infectious Diseases (CRID), Yaoundé, Centre Region, 237, Cameroon;6. Fondation Congolaise pour la Recherche Médicale (FCRM), Brazzaville, Congo;7. Centre de Recherches Médicales de Lambaréné (CERMEL), Lambaréné, Gabon;8. Institute for Tropical Medicine (ITM), University of Tübingen, Tübingen, Germany;9. Eberhard Karls Universität Tübingen, Tübingen, Germany;10. German Center for Infection Research (DZIF), Tübingen, Germany;1. Department of Biological Sciences, Graduate School of Science, the University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan;2. Fukui Prefectural Fisheries Experimental Station, 23-1 Urasoko, Tsuruga, Fukui 914-0843, Japan;3. Sugashima Marine Biological Laboratory, Graduate School of Science, Nagoya University, Toba 517-0004, Japan;4. Faculty of Science, Hokkaido University, N10W8 Kita-ku, Sapporo, Hokkaido 060-0180, Japan |
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| Abstract: | Gastrointestinal nematodes (GIN) of small ruminants have adapted their life history strategies to thrive in diverse and fluctuating environments. Environments which alter their expression of life traits may also drive changes in the infection or transmission dynamics, particularly if transferred to a foreign setting. This study aimed to explore how repeated exposure to a resistant sheep host environment would alter the life history traits and infection dynamics of Teladorsagia circumcincta when consequently infected in susceptible lambs. Following just three generations of passage in resistant sheep, T. circumcincta significantly increased their infectivity and fitness in susceptible lambs compared to a control population. This is the first evidence to indicate the resistant host environment can drive such rapid changes in the expression of GIN life traits, with potentially undesirable epidemiological outcomes. |
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