Recent advances in polysaccharide-based in situ forming hydrogels |
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| Institution: | 1. School of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China;2. Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, United States;3. Department of Sustainable Biomaterials, Virginia Tech, Blacksburg, VA 24061, United States;1. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;2. Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China;3. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China;4. Institute for Cancer Research, Shenzhen Bay Laboratory, Shenzhen, China;1. Department of Chemistry, Virginia Tech, Blacksburg, VA 24061, USA;2. Department of Sustainable Biomaterials, Virginia Tech, Blacksburg, VA 24061, USA;3. Macromolecules Innovation Institute, Virginia Tech, Blacksburg, VA 24061, USA;1. Department of Food Science and Technology, Virginia Tech, 1981 Kraft Dr. Virginia Tech, Blacksburg, VA 24060, USA;2. Department of Chemistry, Virginia Tech, Davidson Hall Room 480, 900 West Campus Drive, Blacksburg, VA 24061, USA;3. Department of Sustainable Biomaterials, Virginia Tech, 230 Cheatham Hall, Blacksburg, VA 24061, USA;4. Macromolecules Innovation Institute, Virginia Tech, 1075 Life Science Circle, Suite 110, Blacksburg, VA 24061, USA;5. Department of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA;1. Macromolecules and Interfaces Institute, Virginia Tech, Blacksburg, VA 24061, United States;2. Department of Sustainable Biomaterials, College of Natural Resources and Environment, Virginia Tech, Blacksburg, VA 24061, United States;3. Department of Chemistry, College of Science, Virginia Tech, Blacksburg, VA 24061, United States |
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| Abstract: | Polysaccharides comprise an important class of natural polymers; they are abundant, diverse, polyfunctional, typically benign, and are biodegradable. Using polysaccharides to design in situ forming hydrogels is an attractive and important field of study since many polysaccharide-based hydrogels exhibit desirable characteristics including self-healing, responsiveness to environmental stimuli, and injectability. These characteristics are particularly useful for biomedical applications. This review will discuss recent discoveries in polysaccharide-based in situ forming hydrogels, including network architecture designs, curing mechanisms, physical and chemical properties, and potential applications. |
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| Keywords: | Polysaccharides Hydrogels Self-healing Biodegradable In situ forming Injectable Benign |
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