Two new aporphine alkaloids with glucose consumption increasing activity from Cassytha filiformis |
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| Affiliation: | 1. Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou 571199, PR China;2. Research Center for Drug Safety Evaluation of Hainan Province, Hainan Medical University, Haikou 571199, PR China;1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China;2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, PR China;3. Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China, Zhengzhou 450046, PR China;1. Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, District 5, Ho Chi Minh City, Viet Nam;2. Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam;3. Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam;4. Department of Biological Resources, Institute of Tropical Biology, VAST, 85 Tran Quoc Toan, Ho Chi Minh City, Viet Nam;1. Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education University of Chinese Medicine, Harbin 150040, PR China;2. Shandong Qingdao Hospital of Integrated Traditional and Western Medicine, PR China;1. Institute of Medical Research and Medicinal Plant Studies, P.O. Box 13033, Yaoundé, Cameroon;2. Bioorganic and Medicinal Chemistry Laboratory, Department of Organic Chemistry, Faculty of Sciences, University of Yaoundé I, P.O Box 812, Yaoundé, Cameroon;3. Department of Chemistry, Higher Teacher Training College Bambili, The University of Bamenda, P.O. Box 39, Bambili, Bamenda, Cameroon;4. Aix-Marseille Univ, CNRS, Centrale Marseille, FSCM, Spectropole, Campus de St Jérôme-Service 511, 13397 Marseille, France;5. Laboratory for Phytobiochemistry and Medicinal Plant Study, Antimicrobial and Biocontrol Agent Unit, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon;6. Aix-Marseille Univ, Avignon Université, CNRS, IRD, IMBE, FAC PHARM, Marseille, France;7. H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;1. INTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Almirante Brown 1455, San Luis D5700ANW, Argentina;2. Instituto de Biotecnología, CONICET, Facultad de Ingeniería, Universidad Nacional de San Juan, Av. Libertador General San Martín 1109 (O), San Juan CP 5400, Argentina;3. Dpto. de Química Orgánica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, INFIQC-CONICET-UNC, Córdoba X5000HUA, Argentina |
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| Abstract: | Two new aporphine alkaloids, named precassythine (1) and (+)− 6S-ocotecine-N-oxide (2), were isolated from Cassytha filiformis. The new structures were elucidated by applying various spectroscopic techniques, including 1D-, 2D NMR and HRESIMS. The absolute configurations of 1 and 2 were determined by calculated electronic circular dichroism (ECD). Both compounds were evaluated for their effects on glucose consumption on HL-7702 cells at different concentrations. The results showed that the two new compounds significantly increased glucose consumption. |
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| Keywords: | Cassytha filiformis Aporphine alkaloids Glucose consumption |
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