Two new compounds from the aerial parts of Elsholtzia densa |
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| Affiliation: | 1. Department of Pharmacology, Basic Medical School of Yangtze University, Jingzhou, Hubei Province, China;2. Department of Pathology and Physiology, Basic Medical School of Yangtze University, Jingzhou, Hubei Province, China;3. Narula Research, Chapel Hill, 27516 NC, USA;4. Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea;1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;2. Institute of Biotechnology, VAST, Hanoi, Viet Nam;1. Department of Chemistry, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka;2. Postgraduate Institute of Science, University of Peradeniya, Sri Lanka;3. Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Sri Lanka;4. Department of Chemistry and Biochemistry, University of Mississippi, MI 38677, United States;1. UMR 152 PharmaDev, Université de Toulouse, IRD, UPS, Toulouse, France;2. Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru;3. Institut de Chimie de Toulouse, ICT UAR 2599, Université Paul Sabatier-Toulouse III, Toulouse, France;1. Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, People’s Republic of China;2. University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China;3. CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266071, People’s Republic of China;4. Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, People’s Republic of China |
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| Abstract: | Two new compounds, named edensa acid (1), and edensaoside A (2), as well as twenty-nine known compounds (3–31) were isolated from the aerial parts of Elsholtzia densa Benth. The chemical structures of the new compounds were determined by spectrometric data interpretation using NMR, HRESIMS, IR and UV spectroscopy. In addition, all compounds were evaluated for their anti-influenza virus activities against A/WSN/33(H1N1). Among these, compounds 18 and 19 exhibited moderate anti-influenza virus activities with IC50 values of 18.79 μM and 59.87 μM respectively. |
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| Keywords: | Chemical constituents Structural identification Anti-influenza virus activities |
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