Pre-diagnostic telomere length and colorectal cancer risk |
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| Affiliation: | 1. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;2. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA;3. Division of Preventive Medicine, Brigham and Women''s Hospital and Harvard Medical School, Boston, MA, USA;4. Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA;5. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA;6. Clinical and Translational Epidemiology Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA;7. Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA;8. Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA;9. Department of Global Health, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA;10. Department of Epidemiology, Richard M. Fairbanks School of Public Health, Indiana University, Indianapolis, IN, USA;1. Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;2. Johns Hopkins Sidney Kimmel Cancer Center, Baltimore, MD, USA;1. Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda;2. Harvard Medical School, Boston, MA, United States;3. Moi University, Eldoret, Kenya;4. Academic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya;5. University of California, San Francisco, CA, United States;6. Masaka Regional Referral Hospital, Masaka, Uganda;7. Mbarara Regional Referral Hospital, Mbarara, Uganda;8. Indiana University, Indianapolis, IN, United States;1. Department of Clinical Epidemiology, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark;2. EpidStrategies, Johns Hopkins Campus , 9601 Medical Center Dr., Rockville, MD 20850, USA;3. SpringWorks Therapeutics, Inc., 100 Washington Blvd., Stamford, CT 06902, USA;4. Musculoskeletal Tumor Section, Department of Orthopedic Surgery, Rigshospitalet, Copenhagen University Hospital, Denmark;5. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark;6. Department of Orthopedic Surgery, Aarhus University Hospital, Denmark;1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China;2. Laboratory for Environmental Toxicology, Anhui Medical University, Hefei , Anhui 230032, China;1. Infections and Cancer Epidemiology Division, German Cancer Research Center (DKFZ), Heidelberg, Germany;2. Department of Research, Cancer Registry of Norway, Oslo, Norway;3. Department of Epidemiology and Biostatistics, Imperial College London, London, UK;4. Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway;5. Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA;6. Cancer Registry of Norway, Oslo, Norway;7. Genetic Epidemiology Group (GEP), International Agency for Research on Cancer (IARC), Lyon, France;8. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA;9. University of Bristol Dental School and University Hospitals Bristol and Weston NHS Foundation Trust Bristol, UK |
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| Abstract: | BackgroundProgressive telomere shortening may be related to genomic instability and carcinogenesis. Prospective evidence relating telomere length (TL) with colorectal cancer (CRC) risk has been limited and inconsistent.MethodsWe examined the association between pre-diagnostic peripheral blood leukocyte TL and CRC risk in two matched case-control studies nested within the Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS). Relative leukocyte TL was measured using qPCR among 356 incident CRC cases and 801 controls (NHS: 186/465, HPFS: 170/336).ResultsWe did not find a significant association between pre-diagnostic TL and CRC risk [in all participants, multivariable-adjusted odds ratio (OR) (95% CI) for TL Quartile 1 (shortest) vs. Quartile 4 (longest) = 1.36 (0.85, 2.17), P-trend = 0.27; OR (95% CI) per 1 SD decrease in TL = 1.12 (0.92, 1.36)].ConclusionsOur prospective analysis did not support a significant association between pre-diagnostic leukocyte TL and CRC risk. |
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| Keywords: | Telomere length Peripheral blood leukocyte Colorectal cancer Colon cancer Rectal cancer Nested case-control study |
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