Two new polycyclic polyprenylated acylphloroglucinols from Hypericum curvisepalum N. Robson |
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| Institution: | 1. School of Pharmacy, Youjiang Medical University for Nationalities, 98 Chengxiang Road, Baise, 533000, PR China;2. Xinjiang Production & Construction Corps Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Tarim University, Alaer, 843300, PR China;3. State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 639 Longmian Road, Nanjing, 211198, PR China;4. Guangxi Database Construction and Application Engineering Research Center for Intracorporal Pharmacochemistry of TCM, 98 Chengxiang Road, Baise, 533000, PR China;1. State Key Laboratory of Component-Based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of China;2. Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, People’s Republic of China;1. Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 40402, Taiwan;2. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung, 40402, Taiwan;3. Endemic Species Research Institute, Council of Agriculture, Nantou, 552203, Taiwan;4. School of Pharmacy, China Medical University, Taichung, 406040, Taiwan;5. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, 40447, Taiwan;1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China;2. University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China;3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210029, PR China;1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;2. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China |
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| Abstract: | Phytochemical investigation of the whole plant of Hypericum curvisepalum led to the isolation of nine polycyclic polyprenylated acylphloroglucinols (1–9). Among them, curvisepalumiones A (1) and B (2) are two new compounds and their structures were elucidated based on extensive spectroscopic data analysis combined with Rh2(OCOCF3)4-induced electronic circular dichroism experiment. Cytotoxic assay showed that all the tested compounds except for 1 was moderately cytotoxic against human hepatocarcinoma cell line SMMC-7721 cell line, while compounds 3 and 4 also exhibited cytotoxicity toward MGC-803 cells. In addition, compound 2 exhibited weak inhibitory activity against Bacillus subtilis. |
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| Keywords: | Polycyclic polyprenylated acylphloroglucinols Antibacterial activity Cytotoxic activity |
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