Limonoids from the bark of Toona ciliata var pubescens and their anti-tumor activities |
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| Affiliation: | 1. Guizhou University of Traditional Chinese Medicine, Guiyang 550025, PR China;2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China;3. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, PR China;1. Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China;2. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), No 28789 Jingshi Dong Road, Jinan 250103, China;3. Shaanxi Key Laboratory of Phytochemistry, Baoji 721013, Shaanxi, China;1. Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China;2. Research Center of Life Science and Biotechnology, School of Life Science, Northeast Agricultural University, Harbin 150030, China;1. College of Biology and Environmental Science, Jishou University, Jishou 416000, China;2. School of Pharmaceutical Sciences, Jishou University, Jishou 416000, China;3. School of Medicine, Jishou University, Jishou 416000, China;4. Key Laboratory of Tujia Medicine Inheritance and Innovation, National Ethnic Affairs Commission of the People''s Republic of China, Jishou University, Jishou 416000, China;5. National Engineering Technology Research Center for Modernization of Traditional Chinese Medicine, Jishou University, Zhuhai 519085, China;1. Thuyloi University, 175 Tay Son, Dong Da, Hanoi, Viet Nam;2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;3. Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;1. Key Laboratory of Standardization of Chinese Medicines, Ministry of Education, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China;2. Shanghai R&D Center for Standardization of Chinese Medicine, Shanghai, China;1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China;2. University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China;3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210029, PR China |
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| Abstract: | Two previously undescribed B-ring seco-limonoids named toonacilinatin I (1) and toonacilinatin J (2), together with ten known analogues (3–12), were isolated from the ethyl acetate extract of the bark of Toona ciliata var pubescens. All structures were elucidated by extensive spectroscopic analysis involving IR, MS, and NMR. Among them, compounds 1–10, and 12 were discovered from this plant for the first time. All the compounds except 7 and 8 were evaluated for their anti-tumor activity by MTT method of MDA-MB-231 and A-673 cell lines, the bioassay results showed that compounds 1, 2, 5, 9 and 11 exerted superior inhibitory activity with IC50 values as 0.11–1.60 μM. Notably, those active compounds exhibited little effect on normal hepatocellular HL-7702 cells. |
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| Keywords: | Limonoids Isolated compounds Anti-tumor |
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