Two new lignans with their biological activities in Portulaca oleracea L. |
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| Affiliation: | 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China;2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, PR China;3. Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China, Zhengzhou 450046, PR China;1. Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, District 5, Ho Chi Minh City, Viet Nam;2. Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam;3. Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam;4. Department of Biological Resources, Institute of Tropical Biology, VAST, 85 Tran Quoc Toan, Ho Chi Minh City, Viet Nam;1. Instituto de Productos Naturales y Agrobiología, C.S.I.C., Avda. Astrofísico F. Sánchez 3, 38206-La Laguna, Tenerife, Canary Islands, Spain;2. Instituto Universitario de Bioorgánica “Antonio González”, Universidad de La Laguna, Tenerife, Spain;1. School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China;2. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi’an 710069, China;1. Key Laboratory of Functional Yeast, China National Light Industry & Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, PR China;2. School of Biotechnology and Food Engineering, Changshu Institute of Technology, Suzhou 215500, PR China;3. Three Gorges Public Inspection and Testing Center, Yichang 443005, PR China;4. Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Three Gorges University Medical College, China Three Gorges University, Yichang 443002, PR China;5. Agricultural College, Hubei Three Gorges Polytechnic, Yichang 443000, PR China;1. Centre des Sciences du Goût et de l′Alimentation, CNRS, INRAE, Institut Agro, Laboratoire de Pharmacognosie, UFR des Sciences de Santé, Université de Bourgogne Franche-Comté, BP 87900, 21079 Dijon Cedex, France;2. Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan;3. Parasitology and Mycology Laboratory, Hôpital du Bocage, BP 77908, 21079 Dijon Cedex, France;4. PAT Zerbaz, 97410 Saint-Pierre, Ile de la Réunion, France |
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| Abstract: | Two new lignans, identified as 6,7-dihydroxy-4-(4′’-hydroxy-3′’-methoxyphenyl)-2-naphthoic acid, named Oleralignan C (1), and 4-(3,4-dihydroxyphenyl)-6-hydroxy-7-methoxy-2-naphthoic acid, named Oleralignan D (2), were obtained from Portulaca oleracea L. The structures were determined by spectroscopic methods, including UHPLC-ESI-QTOFMS, 1D and 2D NMR. Both Oleralignan C (1) and Oleralignan D (2) inhibited the inflammatory factors, IL-1β and TNF-α in RAW 264.7 cells induced by lipopolysaccharide (LPS). Both compounds also could clear 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radicals indicating their antioxidant potential. |
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| Keywords: | Oleralignan Lignan Anti-inflammatory activity Antioxidant activity |
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