N-containing compounds from Hymenocallis littoralis and their cytotoxicity against Hep3B cells |
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| Affiliation: | 1. State Key Laboratory of Component-Based Chinese Medicine, Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, People’s Republic of China;2. Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, People’s Republic of China;1. Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling 712100, China;2. Key Laboratory of Regional Ecological Environment Analysis and Pollution Control of West Guangxi, School of Chemistry and Environment Engineering, Baise University, Baise 533000, China;1. Hubei Key Laboratory of Natural Products Research and Development, Key Laboratory of Functional Yeast (China National Light Industry), College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, PR China;2. Hubei Hongyu New Packing Materials Co., Ltd., Yichang, PR China;1. School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712046, China;2. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi’an 710069, China;1. Department of Food Science, Tunghai University, No. 1727, Sec. 4, Taiwan Boulevard, Xitun District, Taichung, 40704, Taiwan;2. Department of Radiation Oncology, Taichung Veterans General Hospital, No. 1650, Sec. 4, Taiwan Boulevard, Xitun District, Taichung, 40705, Taiwan;1. Department of Biological Medicines, School of Pharmacy, Fudan University, Shanghai 201203, PR China;2. Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, PR China |
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| Abstract: | A chemical study focusing on the N-containing constituents of Hymenocallis littoralis was carried out, leading to the isolation of two new alkaloidal flavonoids (1–2) and five known alkaloids (3-7). Structures of the isolated compounds were established mainly by spectroscopic techniques, including NMR spectroscopy and mass spectrometry as well as the CD experiment. These compounds were subjected to the in vitro cytotoxicity assays using Hep3B cells, and among them only the known pancratistatine (3) and lycorine (5) could significantly inhibit the Hep3B cell proliferation. |
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| Keywords: | N-containing constituents Flavonoid alkaloid Hep3B cells Cytotoxicity |
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