Breast cancer trends in women younger than 40 years in Brazil |
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| Affiliation: | 1. Faculty of Medicine, University of Iceland, Reykjavik, Iceland;2. Department of Pathology, Landspitali University Hospital of Iceland, Reykjavik, Iceland;3. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Landspitali University Hospital of Iceland, Reykjavik, Iceland;1. HCA Florida Brandon Hospital Department of Internal Medicine, 119 Oakfield Drive, Brandon, FL 33511, USA;2. University of Kansas School of Medicine Department of Population Health, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA;3. University of Kansas Cancer Center, 4000 Cambridge Street, Kansas City, KS 66160, USA;7. Pediatric Hematology-Oncology Unit, 1st Department of Pediatrics, ''A. Sofia'' Children''s Hospital, Athens, Greece;8. Department of Pediatric Hematology-Oncology, "Agia Sofia" Children''s Hospital, Athens, Greece;9. Department of Pediatric Hematology and Oncology, Hippokration Hospital, Thessaloniki, Greece;10. Hematology-Oncology Unit, 2nd Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece;11. Department of Pediatric Hematology-Oncology, University of Crete, University Hospital of Heraklion, Heraklion, Greece;12. Department of Pediatric and Adolescent Hematology-Oncology ''Mitera'' Children''s Hospital, Athens, Greece;13. Department of Pathology, Children''s Hospital "Agia Sofia", Athens, Greece;14. Pathology Laboratory, "P & A Kyriakou" Children''s Hospital, Athens, Greece;15. Department of Paediatric Radiology (CT & MRI) and Nuclear Medicine, ''Aghia Sophia'' Children''s Hospital, Athens, Greece;p. Children''s & Adolescents Radiotherapy Department - Athens General Children''s Hospital "P. & A. Kyriakou", Athens, Greece;1. Hellenic Society for Social Pediatrics and Health Promotion, Athens, Greece;2. Department of Pediatric Hematology-Oncology, "P&A Kyriakou" Children''s Hospital, Athens, Greece;3. Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece;4. Center for Evidence Synthesis in Health, Brown University School of Public Health, Providence, RI, USA;5. Section of Cancer Surveillance, International Agency for Research on Cancer (IARC), Lyon, France;6. Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece;1. Departamento de Medicina Legal, Etica Medica, Medicina Social e do Trabalho, Instituto Oscar Freire, LIM-40, Faculdade de Medicina da Universidade de Sao Paulo (FMUSP), Av Dr. Arnaldo, 455, Sao Paulo, Brazil;2. Centro de Investigação Translacional em Oncologia, Instituto do Cancer do Estado de Sao Paulo, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Av Dr. Arnaldo, 251, Sao Paulo, Brazil;3. Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia, Hospital Heliopolis, R Cônego Xavier, 276, Sao Paulo, Brazil;1. ICES, Toronto, Canada;2. Manitoba Centre for Health Policy, Department of Community Health Sciences, University of Manitoba, Winnipeg, Canada;3. Faculty of Health, Dalhousie University, Halifax, Canada;4. Dalla Lana School of Public Health, University of Toronto, Toronto, Canada;5. School of Rehabilitation Therapy, Queen’s University, Kingston, Canada;6. Institute for Health Policy, Management, and Evaluation, University of Toronto, Toronto, Canada |
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| Abstract: | BackgroundA recent Brazilian populational database analysis showed a concerning increase in breast cancer mortality rates among patients under 40 years. We aimed to evaluate the trends in the proportion of new breast cancer cases and deaths occurring in patients younger than 40 years over the last decade in Brazil.MethodsWe evaluated all consecutive breast cancer patients treated from 2009 to 2020 in a Brazilian tertiary cancer center. The proportions of new cases and deaths in patients younger than 40 years was compared between two time periods (2015–2020 versus 2009–2014) using Chi-squared test. Linear regression was used to evaluate the trends in the proportion of new cases and deaths in young patients over the years.ResultsFrom 2009 to 2020, a total of 12,569 breast cancer patients started treatment at our institution; 1441 were younger than 40 years. From 2009 to 2014, 9.9% (95% CI 9.2–10.7%) were patients younger than 40 years compared to 12.9% (95% CI 12.1–13.8%) from 2015 to 2020. Similarly, the proportion of deaths among breast cancer patients younger than 40 years increased during the period (2009–2014: 9.6%, 95% CI 7.8–11.6%; 2015–2020: 12.4%, 95% CI 10.9–14%). The linear regression model showed a trend for an increasing proportion of new breast cancer cases occurring in patients under 40 years (P = 0.005). Proportion increased from 7.9% (95% CI 6.2–9.8%) in 2009 to 21.8% (95% CI 19.1–24.8%) in 2020. The trend for the increase in the proportion of deaths in this young population was also observed in the linear regression model (P = 0.01).ConclusionsThe proportion of new breast cancer cases and deaths among patients younger than 40 years has increased in a public Brazilian cancer center over the past decade. These results raise the concern for the need to reconsider primary and secondary prevention strategies for young women. |
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| Keywords: | Breast cancer Young ages Cancer trends Incidence Mortality 40 years |
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