The origins,isolation, and biological characterization of rodent malaria parasites |
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| Institution: | 1. Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand;2. Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD, USA;1. Key Lab of Environment and Health, School of Public Health, Xuzhou Medical University, No.209, Tongshan Road, Xuzhou 221004, Jiangsu, China;2. Yunnan Institute of Parasitic Diseases, No.6 Xiyuan Road, Simao City, Puer 665000, Yunnan, China;3. Jinan Blood Center, No.127 Jingliu Road, Jinan 250001, Shandong, , China;1. School of Science, Mae Fah Luang University, Chiang Rai, Thailand;2. Gut Microbiome Research Group, Mae Fah Luang University, Chiang Rai, Thailand;3. Laboratory of Molecular and Evolutionary Parasitology, RAPID Group, School of Biosciences, University of Kent, Canterbury, United Kingdom;1. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA;1. ICMR-National Institute of Malaria Research, India;2. Academy of Scientific and Innovative Research, India;3. Molecular Medicine, International Centre for Genetic Engineering & Biotechnology, India;1. Cell and Molecular Biology Laboratory, Department of Zoology, Soban Singh Jeena University, Campus Almora, Uttarakhand, India;2. Department of Zoology, Kumaun University, Nainital, Uttarakhand, India |
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| Abstract: | Rodent malaria parasites have been widely used in all aspects of malaria research to study parasite development within rodent and insect hosts, drug resistance, disease pathogenesis, host immune response, and vaccine efficacy. Rodent malaria parasites were isolated from African thicket rats and initially characterized by scientists at the University of Edinburgh, UK, particularly by Drs. Richard Carter, David Walliker, and colleagues. Through their efforts and elegant work, many rodent malaria parasite species, subspecies, and strains are now available. Because of the ease of maintaining these parasites in laboratory mice, genetic crosses can be performed to map the parasite and host genes contributing to parasite growth and disease severity. Recombinant DNA technologies are now available to manipulate the parasite genomes and to study gene functions efficiently. In this chapter, we provide a brief history of the isolation and species identification of rodent malaria parasites. We also discuss some recent studies to further characterize the different developing stages of the parasites including parasite genomes and chromosomes. Although there are differences between rodent and human malaria parasite infections, the knowledge gained from studies of rodent malaria parasites has contributed greatly to our understanding of and the fight against human malaria. |
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