Five new diterpenoid alkaloids from Aconitum sczukinii Turcz. |
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| Affiliation: | 1. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China;2. School of Chemical Science and Technology, Yunnan University, Kunming 650091, People’s Republic of China;3. Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, People’s Republic of China;1. Centro de Investigaciones en Productos Naturales, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;2. Centro de Investigación en Biología Celular y Molecular, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;3. Centro de Electroquímica y Energía Química, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;4. Escuela de Química, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;1. School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, 510006, China;2. Guangdong Engineering Research Center for Lead Compounds & Drug Discovery, Guangzhou, 510006, China;1. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin, 541006, China;2. College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, 530200, China;1. The Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China;2. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China;3. University of Chinese Academy of Sciences, Beijing, 100039, PR China;1. Key Laboratory of Medicinal Animal and Plant Resources of Qinghai-Tibetan Plateau in Qinghai Province, Qinghai Normal University, Xining, 810008, PR China;2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, PR China;3. Bijie Medical College, Bijie, 551700, PR China;4. The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, PR China |
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| Abstract: | Ten diterpenoid alkaloids, including five new ones, sczukiniline A–E (1-5), were isolated from the root of Aconitum sczukinii. Their structures were elucidated based on the interpretation of spectroscopic data (HRESI-MS, IR, 1D- and 2D-NMR). Among the five new diterpenoid alkaloids, 1-3 are hetidine-type C20-diterpenoid alkaloids, while compounds 4 and 5 are lycoctonine-type C19-diterpenoid alkaloids. Noteworthily, sczukiniline A (1) features a novel ester group between C-12 and C-14, forming a D ring containing a lactone structure, resulting in a new skeleton of hetidine-type C20-diterpenoid alkaloid. |
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| Keywords: | Ranunculaceae Diterpenoid alkaloid Sczukiniline |
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