Cordiosides A and B,two new 19-hydroxy-29-norlanostane glycosides isolated from the flowers of Cordia lutea |
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| Affiliation: | 1. UMR 152 PharmaDev, Université de Toulouse, IRD, UPS, Toulouse, France;2. Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru;3. Institut de Chimie de Toulouse, ICT UAR 2599, Université Paul Sabatier-Toulouse III, Toulouse, France;1. Research Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;2. Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;3. Université de Reims Champagne Ardenne, CNRS, ICMR UMR 7312, 51097 Reims, France;4. Food Science, Department of Chemistry, Carleton University, Room 207D Steacie Building, 1125 Colonel by Drive, K1S 5B6 Ottawa, Canada;1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;2. Institute of Biotechnology, VAST, Hanoi, Viet Nam;1. Nation-Regional Engineering Lab for Synthetic Biology of Medicine, International Cancer Center, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China;2. Shenzhen Key Laboratory for Nano-Biosensing Technology (ZDSYS20210112161400001), Shenzhen University Health Science Center, Shenzhen 518060, China;1. Beijing Key laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China;2. College of Food Science and Technology, Henan Agricultural University, Zhengzhou 450002, China;1. Department of Chemistry, Faculty of Science, University of Peradeniya, Peradeniya, Sri Lanka;2. Postgraduate Institute of Science, University of Peradeniya, Sri Lanka;3. Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Sri Lanka;4. Department of Chemistry and Biochemistry, University of Mississippi, MI 38677, United States |
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| Abstract: | We present here the isolation and structural characterization of two undescribed mono-glycosylated triterpenes with a 19-hydroxy-29-norlanostane core. These compounds (1-2) were isolated from an ethanolic extract of the dried flowers of Cordia lutea, a widely used Peruvian traditional medicine. Their structures were determined by examination of their NMR and MS data. For compound 1, its structure was confirmed by single crystal X-ray structural analyses. 1 showed moderate activity against Helicobacter pylori (MIC = 15.6 µg/mL), and was not active against Escherichia coli, Pseudomonas aeruginosa or Staphylococcus aureus (MIC > 125 µg/mL). |
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| Keywords: | Boraginaceae Antibacterial 19-Hydroxy-29-norlanostane Peruvian traditional medicine |
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