Cytotoxic diterpenoids from the aerial parts of Scoparia dulcis |
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| Institution: | 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China;2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, PR China;1. Laboratoire de Chimie et Chimie de l′Environnement (LCCE), Département de Chimie, Faculté des Sciences de la Matière, Université de Batna-1, Batna, Algérie;2. Faculté des Sciences de la Nature et de la vie, Université de Batna-2, Batna, Algérie;3. Laboratoire de Biotechnologie des molécules bioactives et de la physiopathologie cellulaire, Département de biologie, Faculté des Sciences de la Nature et de la vie, Université de Batna-2, Batna, Algérie;4. LAQV-REQUIMTE & Department of Chemistry, University of Aveiro, 810-193 Aveiro, Portugal;1. School of Biological Science and Technology, University of Jinan, Jinan 250012, China;2. Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China;3. Shandong Provincial Engineering Research Center for Medicines of Orthopedic Pain, Shandong Mingren Freda Pharmaceutical Co., Ltd, Jinan 250104, China;1. Department of Biological Medicines, School of Pharmacy, Fudan University, Shanghai 201203, PR China;2. Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, PR China;1. Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education & Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, China;2. Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou, 570311, China;1. School of Ethnic Medicine, Yunnan University of Chinese Medicine, Kunming 650500, Yunnan, PR China;2. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, Yunnan, PR China;3. Key Laboratory of Modern Research on Ethnic Medicine in Colleges of Yunnan Province, Yunnan University of Chinese Medicine, Kunming 650500, Yunnan, PR China;4. Yunnan Phytopharmaceutical Co. Ltd., Kunming 650505, Yunnan, PR China;5. School of Chemical Biology & Environment, Yuxi Normal University, Yuxi 653100, Yunnan, PR China |
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| Abstract: | Two formerly undescribed labdane-type diterpenoids, scoparicols C (1) and D (2), one previously unreported scopadulane-type diterpenoid 1β-hydroxydulcinodal-13-one (3), along with six known biogenetically related analogs (4?9) were separated from the aerial parts of a traditional ethnological herb, Scoparia dulcis. Spectroscopic techniques including MS NMR and ECD were employed to characterize the structures of these molecules. While the oxidation at C-1 in 3 was reported for scopadulane-type diterpenoids for the first time, compound 7 was first obtained as a natural product in the present work. The cytotoxicity of all the isolates against four tumor cell lines (MCF-7, MDA-MB231, Hela and A549) were tested, with selective compounds showing activity in the IC50 range of 4.31–28.6 μM. |
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| Keywords: | Scrophulariaceae Scopadulane diterpenoid Labdane diterpenoid Cytotoxicity |
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