Two new guaiane-sesquiterpenes from the cultured lichen mycobiont of Diorygma pruinosum |
| |
| Institution: | 1. NTT Hi-Tech Institute, Nguyen Tat Thanh University, 300A Nguyen Tat Thanh, District 4, Ho Chi Minh City, Viet Nam;2. Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand;3. Faculty of Applied Technology, School of Engineering and Technology, Van Lang University, Binh Thanh District, Ho Chi Minh City, Viet Nam;4. Faculty of Biology-Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City, Viet Nam;5. CirTech Institute, HUTECH University, 475A Dien Bien Phu Street, Binh Thanh District, Ho Chi Minh City, Viet Nam;6. Department of Chemistry, Ho Chi Minh City University of Education, 280 An Duong Vuong Street, District 5, Ho Chi Minh City 748342, Viet Nam;1. Research Unit of Environmental and Applied Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;2. Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon;3. Université de Reims Champagne Ardenne, CNRS, ICMR UMR 7312, 51097 Reims, France;4. Food Science, Department of Chemistry, Carleton University, Room 207D Steacie Building, 1125 Colonel by Drive, K1S 5B6 Ottawa, Canada;1. Beijing Key Labrotary for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing, China;2. Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China;1. Nation-Regional Engineering Lab for Synthetic Biology of Medicine, International Cancer Center, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China;2. Shenzhen Key Laboratory for Nano-Biosensing Technology (ZDSYS20210112161400001), Shenzhen University Health Science Center, Shenzhen 518060, China;1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China;2. College of Life Sciences, Inner Mongolia Agricultural University, Hohhot 010018, PR China;3. College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, PR China;4. Inner Mongolia Grand Pharmaceutical Co., Ltd, Hohhot 010010, PR China |
| |
| Abstract: | Lichens and the mycobionts derived from lichen-source are believed to be a valuable source of bioactive compounds. Diorygma pruinosum is a native lichen in Vietnam. A mycobiont of Diorygma pruinosum was separated, then cultivated. Phytochemical data on this lichen and its cultured mycobionts are scarce. The present study described the isolation and structural elucidation of two new guaiane-type sesquiterpenes, namely pruinosone (1) and hydroxypruinosone (2). Their absolute chemical structures were elucidated by extensive 1D and 2D NMR analysis, high-resolution mass spectroscopy, electronic circular dichroism (ECD), and comparisons in the literatures. Compounds 1 and 2 were evaluated for alpha-glucosidase inhibition and antimicrobial activity. |
| |
| Keywords: | Cultured lichen mycobiont Guaiane Pruinosone |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
