Evaluation of target-specific natural compounds for drug discovery against Leishmaniasis |
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| Institution: | 1. Cell and Molecular Biology Laboratory, Department of Zoology, Soban Singh Jeena University, Campus Almora, Uttarakhand, India;2. Department of Zoology, Kumaun University, Nainital, Uttarakhand, India;1. Laboratório de Imunidade Natural (LIN), Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Goiás, Brazil;2. Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil;1. Department of Veterinary Parasitology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125004, India;2. Parasitology Lab, ICAR-National Research Centre on Equines, Hisar, Haryana 125001, India;3. Department of Veterinary Physiology and Biochemistry, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125004, India;1. Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510542, China;2. Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt;1. Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, Brazil;2. Universidade Regional Integrada Alto Uruguai e Missões, Sete de Setembro Avenue, 1621, Erechim, Rio Grande do Sul 99709-910, Brazil;3. Programa de Pós-graduação em Bioquímica, Universidade Federal do Pampa, BR 472, Km 585, Uruguaiana, RS, Brazil;4. Clinica Silveira, Sete de Setembro Avenue, 1502, Erechim, Rio Grande do Sul, Brazil |
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| Abstract: | Leishmaniasis is a parasitic disease with no effective vaccine still now. Globally, it has affected millions of people, precisely in the undeveloped and developing countries. The control strategy for leishmaniasis depends only on chemotherapeutic methods that are associated with several side effects. Therefore, to overcome these negative impacts natural products are the best alternative for developing effective herbal-based drugs, which can act as one of the safest and effective alternative options to treat this particular disease. Leishmania, the causative agent of this disease possesses unique enzymes and metabolic pathways that are different from its mammalian host. Moreover, these unique enzymes, along with the signaling molecules and metabolic pathways that are crucial for its survival, serve as a suitable drug target for the evaluation of specific natural inhibitors to overcome leishmaniasis. Hence, in this review, we have discussed various specific targets of Leishmania, along with their natural inhibitors which can play a significant role in anti-leishmanial drug discovery. |
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