Euphane and friedelane triterpenoids from Tripterygium wilfordii |
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Affiliation: | 1. BioBioPha Co., Ltd., Kunming, 650201, People’s Republic of China;2. Reference Substance Branch, National Engineering Research Center for Modernization of Traditional Chinese Medicine, Kunming, 650201, People’s Republic of China;1. Centro de Investigaciones en Productos Naturales, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;2. Centro de Investigación en Biología Celular y Molecular, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;3. Centro de Electroquímica y Energía Química, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;4. Escuela de Química, Universidad de Costa Rica, San José, 11501-2060, Costa Rica;1. Department of Pharmaceutical Engineering, Shanxi Pharmaceutical Vocational College, Taiyuan, 030031, People’s Republic of China;2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China;3. Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China;1. VNU University of Science, Vietnam National University, Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam;2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam;3. Institute of Biotechnology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam;1. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin, 541006, China;2. College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, 530200, China;1. Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China;2. Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Key Laboratory of Agro-products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193, China;1. College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming, 650500, China;2. Department of Oncology, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, 650599, China |
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Abstract: | Four hitherto unknown triterpenoids, including one euphane, namely wilfordeuphone (1), and three friedelanes, namely wilforic acids G − I (2–4), were isolated from the ethanol extract of the roots of Tripterygium wilfordii. The absolute configuration of 1 was established by single crystal X-ray diffraction. In addition, this study is the first to report euphane-type triterpenoid in the genus Tripterygium. Compound 1 exhibited the moderate cytotoxic activity when evaluated against five human cancer cell lines (HL-60, A-549, SMMC-7721, MCF-7, and SW-480), with IC50 values ranging from 14.0–26.7 μM. |
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Keywords: | Triterpenoid Euphane Friedelane Single crystal X-ray diffraction |
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