Two new polyhydroxylated steroidal glycosides from Paris polyphylla var. yunnanensis |
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| Affiliation: | 1. Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration Biodiversity Conservation, Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China;2. University of Chinese Academy of Sciences, Beijing 100049, China;3. Engineering Research Center for Pharmaceuticals and Equipments of Sichuan Province, Sichuan Industrial Institute of Antibiotics, School of Pharmacy, Chengdu University, Chengdu 610106, China;1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China;2. Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, 101 longmian Avenue, Nanjing 211166, PR China;1. School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, PR China;2. National Demonstration Center for Experimental Ethnopharmacology Education, South-Central Minzu University, Wuhan 430074, PR China;1. School of Biological Science and Technology, University of Jinan, Jinan 250012, China;2. Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China;3. Shandong Provincial Engineering Research Center for Medicines of Orthopedic Pain, Shandong Mingren Freda Pharmaceutical Co., Ltd, Jinan 250104, China;1. Thuyloi University, 175 Tay Son, Dong Da, Hanoi, Viet Nam;2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;3. Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, People''s Republic of China;2. National Engineering Research Center for Modernization of Traditional Chinese Medicine, Weihe Pharmaceutical Co., Ltd., Yuxi 653101, People''s Republic of China;1. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People’s Republic of China;2. Research Institute, Lanzhou Jiaotong University, Lanzhou 730070, People’s Republic of China |
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| Abstract: | Chemical investigation of Paris polyphylla smith var. yunnanensis afforded two new polyhydroxylated steroidal glycosides, named Parisyunnanosides K and L (1–2), together with nine known ones. The chemical structures of the new compounds were elucidated by 1D, 2D NMR and HR-ESI-MS techniques, together with chemical methods. Parisyunnanosides K and L (1–2) are rare C27 steroidal glycosides with two double bonds located at C-5, 6 and C-25, 26 of the aglycone, respectively. The cytotoxic activities of the isolated compounds were evaluated against Caco-2 cells by CCK-8 assay. Among them, compounds 5–11 exhibited potent cytotoxic activity with IC50 values ranging from 1.10 to 14.14 μM compared with the positive control oxaliplatin (1.38 μM). |
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| Keywords: | Parisyunnanosides K and L Cytotoxic activity |
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