Iridoids and lignans from Valeriana officinalis L. and their cytotoxic activities |
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| Institution: | 1. College of Life Sciences, Yunnan University, Kunming, Yunnan 650091, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;3. International Institute for Translational Chinese Medicine, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, China;4. An Shun City People’s Hospital, Anshun 561000, China;5. Yunnan University of Traditional Chinese Medicine, Yunnan 650500, China;6. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China;1. Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China;2. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), No 28789 Jingshi Dong Road, Jinan 250103, China;3. Shaanxi Key Laboratory of Phytochemistry, Baoji 721013, Shaanxi, China;1. School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, PR China;2. National Demonstration Center for Experimental Ethnopharmacology Education, South-Central Minzu University, Wuhan 430074, PR China;1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;2. National Biobank of Thailand, 114 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;3. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People’s Republic of China;1. College of Biology and Environmental Science, Jishou University, Jishou 416000, China;2. School of Pharmaceutical Sciences, Jishou University, Jishou 416000, China;3. School of Medicine, Jishou University, Jishou 416000, China;4. Key Laboratory of Tujia Medicine Inheritance and Innovation, National Ethnic Affairs Commission of the People''s Republic of China, Jishou University, Jishou 416000, China;5. National Engineering Technology Research Center for Modernization of Traditional Chinese Medicine, Jishou University, Zhuhai 519085, China;1. Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944401, Taiwan;2. National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan;3. Division of Dentistry, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813204, Taiwan;4. Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804201, Taiwan;5. Department of Nursing, Fooyin University, Kaohsiung 831301, Taiwan;6. Clinical Immunology Laboratory, Department of Medical Research, E-Da Hospital, Kaohsiung 824005, Taiwan;7. Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802301, Taiwan;8. Center for General Education, Cheng Shiu University, Kaohsiung 833301, Taiwan;9. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan;10. Institute of BioPharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung 804201, Taiwan;11. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan;12. Research Center for Chinese Herbal Medicine, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan;13. Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan;14. Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan;15. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404332, Taiwan;p. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807378, Taiwan;q. Ph.D. Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei 242062, Taiwan |
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| Abstract: | Two new iridoids (1 and 2), one new lignan (3) together with one known iridoid (4) and twelve known lignans (5－16) were obtained from the roots of Valeriana officinalis L. (V. officinalis). The structures were determined using IR, MS, 1D and 2D NMR spectroscopy and the absolute configurations of the new structures were deduced by ECD experiments. All of the isolated compounds were assayed for their cytotoxic activities against three tumour cell lines (A549, HCT116 and SW620) and the results showed that compounds 9 and 10 showed cytotoxicities against A549 cells, compounds 9 and 11 showed cytotoxicities against SW620 cells and compound 10 showed cytotoxicities against HCT116 cells. |
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| Keywords: | Structure determination Lignans Iridoids Cytotoxic activities |
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