Two new alkaloids from Pachysandra terminalis and their antibacterial activity assessment |
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| Institution: | 1. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pharmacy, Peking University Cancer Hospital & Institute, Beijing 100142, China;2. Department of Stomatology, the Eighth Medical Center, Chinese PLA General Hospital, Beijing 100091, China;3. Department of Pharmacy, Beijing Tiantan Hospital affiliated to Capital Medical University, Beijing 100070, China;4. Department of Pharmacy, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, China;5. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Division of Gastrointestinal Cancer Translational Research Laboratory, Peking University Cancer Hospital & Institute, Beijing, China;6. Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Air Force Medical University, Xi''an, Shaanxi 710032, China;1. Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;2. Faculty of Natural Resources and Environment, Vietnam National University of Agriculture, Trau Quy, Gia Lam, Hanoi, Viet Nam;3. Institut de Chimie des Substances Naturelles, CNRS-ICSN, UPR 2301, Université Paris-Saclay, 91198, Gif-sur-Yvette, France;4. School of Chemical Engineering, Hanoi University of Science and Technology, 1 Dai Co Viet, Hai Ba Trung, Hanoi, Viet Nam;5. Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam;1. Thuyloi University, 175 Tay Son, Dong Da, Hanoi, Viet Nam;2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;3. Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;1. College of Biology and Environmental Science, Jishou University, Jishou 416000, China;2. School of Pharmaceutical Sciences, Jishou University, Jishou 416000, China;3. School of Medicine, Jishou University, Jishou 416000, China;4. Key Laboratory of Tujia Medicine Inheritance and Innovation, National Ethnic Affairs Commission of the People''s Republic of China, Jishou University, Jishou 416000, China;5. National Engineering Technology Research Center for Modernization of Traditional Chinese Medicine, Jishou University, Zhuhai 519085, China;1. Key Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, College of Life Science, Huzhou University, Huzhou 313000, China;2. Research Center of Life Science and Biotechnology, School of Life Science, Northeast Agricultural University, Harbin 150030, China;1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China;2. Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, 101 longmian Avenue, Nanjing 211166, PR China |
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| Abstract: | Phytochemical investigation of a 90 % ethanol extract of Pachysandra terminalis Sieb. Et Zucc led to the isolation of a novel alkaloid, terminamine T (1); a new pregnane-type alkaloid, terminamine U (2); and four known pregnane-type alkaloids (3-6). The structures of these compounds were elucidated on the basis of nuclear magnetic resonance spectra, mass spectrometry data, single-crystal X-ray diffraction, and by a comparison with data from the literature. All compounds were evaluated for their antibacterial activities against gram-positive (S. aureus, ATCC 29213) and gram-negative (E. coli, ATCC 25922) bacteria. Compounds 2-6 exhibited generally modest to poor antibiotic properties. Furthermore, compound 2 showed antibacterial activity against methicillin-resistant Staphylococcus epidermidis (MRSE), methicillin-resistant Staphylococcus aureus (MRSA), and methicillin-resistant Staphylococcus aureus USA300 (LAC) with a minimal inhibitory concentration (MIC) value of 32 μg/mL (75 μM) and minimum bactericidal concentration (MBC) values of 64, 128, and 128 μg/mL (150, 300, and 300 μM), respectively. |
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| Keywords: | Alkaloids Pregnane-type alkaloids Antibacterial activity |
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