Bisstyryl constituents from the leaves of Miliusa sinensis |
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| Affiliation: | 1. Thuyloi University, 175 Tay Son, Dong Da, Hanoi, Viet Nam;2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;3. Institute of Ecology and Biological Resources, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam;1. School of Biological Science and Technology, University of Jinan, Jinan 250012, China;2. Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China;3. Shandong Provincial Engineering Research Center for Medicines of Orthopedic Pain, Shandong Mingren Freda Pharmaceutical Co., Ltd, Jinan 250104, China;1. School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, PR China;2. National Demonstration Center for Experimental Ethnopharmacology Education, South-Central Minzu University, Wuhan 430074, PR China;1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China;2. Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, 101 longmian Avenue, Nanjing 211166, PR China;1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;2. National Biobank of Thailand, 114 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;3. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People’s Republic of China;1. College of Biology and Environmental Science, Jishou University, Jishou 416000, China;2. School of Pharmaceutical Sciences, Jishou University, Jishou 416000, China;3. School of Medicine, Jishou University, Jishou 416000, China;4. Key Laboratory of Tujia Medicine Inheritance and Innovation, National Ethnic Affairs Commission of the People''s Republic of China, Jishou University, Jishou 416000, China;5. National Engineering Technology Research Center for Modernization of Traditional Chinese Medicine, Jishou University, Zhuhai 519085, China;1. Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 944401, Taiwan;2. National Museum of Marine Biology and Aquarium, Pingtung 944401, Taiwan;3. Division of Dentistry, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 813204, Taiwan;4. Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804201, Taiwan;5. Department of Nursing, Fooyin University, Kaohsiung 831301, Taiwan;6. Clinical Immunology Laboratory, Department of Medical Research, E-Da Hospital, Kaohsiung 824005, Taiwan;7. Division of Neurosurgery, Department of Surgery, Kaohsiung Armed Forces General Hospital, Kaohsiung 802301, Taiwan;8. Center for General Education, Cheng Shiu University, Kaohsiung 833301, Taiwan;9. Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan;10. Institute of BioPharmaceutical Sciences, National Sun Yat-sen University, Kaohsiung 804201, Taiwan;11. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333323, Taiwan;12. Research Center for Chinese Herbal Medicine, Graduate Institute of Healthy Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan;13. Department of Anaesthesiology, Chang Gung Memorial Hospital, Taoyuan 333423, Taiwan;14. Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan;15. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404332, Taiwan;p. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807378, Taiwan;q. Ph.D. Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei 242062, Taiwan |
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| Abstract: | Miliusa sinensis Finet and Gagnep. have recently been subjected to numerous scientific studies pursuing its structure and biological properties. The chromatographic separation of the components from the methanolic extract of M. sinensis leaves yielded three new bisstyryls, namely, sinenbisstyryls A–C (1–3). The structures of the new compounds were determined via interpretation of their spectroscopic data. Of the isolated compounds, sinenbisstyryl A (1) exhibited cytotoxic activity against the A549 human lung, HepG2 human hepatocyte carcinoma, MCF7 human breast, and DU145 human prostate cancer cell lines, with IC50 values of between 11.46 μM and 19.01 μM in four cases. |
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| Keywords: | Annonaceae Bisstyryl compound Sinenbisstyryls A–C Cytotoxic activity |
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