Genetic polymorphism of circumsporozoite protein (CSP) in Plasmodium malariae isolates from Malaysia |
| |
| Institution: | 1. Department of Parasitology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia;2. Public Health Laboratory Kota Kinabalu (Ministry of Health Malaysia), 88850 Kota Kinabalu, Sabah, Malaysia;1. College of the Environment & Ecology, Xiamen University, 361102 Xiamen, Fujian Province, PR China;2. Key Laboratory of Molecular Cell Biology, Ministry of Education of the People''s Republic of China; Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province; College of Life Sciences, Hebei Normal University, 050024 Shijiazhuang, Hebei Province, PR China;3. Key Laboratory of Food Safety Risk Assessment, National Health Commission of the People''s Republic of China, China National Center for Food Safety Risk Assessment (CFSA), 100021 Beijing, PR China;1. Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;3. University “St. Kliment Ohridski”, Faculty of Biotechnical Sciences, Bitola, R. N. Macedonia;1. Laboratory of Parasitology, Joint Graduate School of Veterinary Medicine, Yamaguchi University, Japan;2. Laboratory of Nematology, Faculty of Agriculture, Saga University, Japan;3. Laboratory of Parasitology, School of Veterinary Medicine, Azabu University, Japan |
| |
| Abstract: | Information about Plasmodium malariae is scanty worldwide due to its “benign” nature and low infection rates. Consequently, studies on the genetic polymorphisms of P. malariae are lacking. Here, we report genetic polymorphisms of 28 P. malariae circumsporozoite protein (Pmcsp) isolates from Malaysia which were compared with those in other regions in Asia as well as those from Africa. Phylogenetic analysis revealed that most Malaysian P. malariae isolates clustered together but independently from other Asian isolates. Low nucleotide diversity was observed in Pmcsp non-repeat regions in contrast to high nucleotide diversity observed in non-repeat regions of Plasmodium knowlesi CSP gene, the current major cause of malaria in Malaysia. This study contributes to the characterisation of naturally occurring polymorphisms in the P. malariae CSP gene. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
