Cucurbitane-type triterpenoids from the branches and leaves of Elaeocarpus sylvestris |
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| Affiliation: | 1. Key Laboratory of Economic Plants and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources, and State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China;2. School of Life Sciences, Yunnan University, Kunming 650500, People’s Republic of China;3. Yuxi Cigarette Factory, Hongta Tobacco Group Co., Ltd., Yuxi 653100, People’s Republic of China;1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China;2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, PR China;3. Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan & Education Ministry of P.R. China, Zhengzhou 450046, PR China;1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China;2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, PR China;1. Faculty of Chemistry, VNUHCM-University of Science, 227 Nguyen Van Cu, District 5, Ho Chi Minh City, Viet Nam;2. Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Viet Nam;3. Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Viet Nam;4. Department of Biological Resources, Institute of Tropical Biology, VAST, 85 Tran Quoc Toan, Ho Chi Minh City, Viet Nam;1. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, People''s Republic of China;2. Affiliated Hospital of Southwest Jiaotong University ＆ The Third People Hospital of Chengdu, Chengdu 610031, Sichuan, People''s Republic of China;3. Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, Sichuan, People''s Republic of China;1. Hunan Province Cooperative innovation Center for Molecular Target New Drug Study, the Key Laboratory of Environment and Critical Human Diseases Prevention of the Education Department of Hunan Province, Hengyang Medical School, University of South China, Hengyang 421001, China;2. College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China;3. South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China |
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| Abstract: | The chemical structures of nine cucurbitane-type triterpenoids from the branches and leaves of Elaeocarpus sylvestris (Elaeocarpaceae), including undescribed 29-hydroxymogroside I E2, epimogroside I E2, epimogroside I E1, 24-oxomogroside I E1, and 11-O-acetylmogroside I E1, were determined using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. The absolute configuration of 29-hydroxymogroside I E2 was confirmed by performing an X-ray diffraction analysis. Cucurbitacin D and 11-O-acetylmogroside I E1 showed cytotoxicity toward human leukemia HL-60, human lung adenocarcinoma A549, human hepatoma SMMC-7721, human breast cancer MCF-7, and human colon cancer SW480 cell lines. The presence of a 11-O-acetyl group might increase the cytotoxicity of this type of triterpenoids. |
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| Keywords: | Elaeocarpaceae Cucurbitane-type triterpenoids Cytotoxicity |
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