Chemical constituents from Abrus cantoniensis and their cytotoxic effects on cancer cells |
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| Institution: | 1. Department of Basic Medicine, Zhaoqing Medical College, Guangdong 526020, China;2. Department of Nursing, Foshan University Medical College, Guangdong 528000, China;1. College of Pharmacy, Fujian University of Traditional Chinese Medicine, No.1 Qiuyang Road, Fujian 350108, PR China;2. Department of Phytochemistry, School of Pharmacy, Naval Medical University, No. 325, Guohe Road, Shanghai 200433, PR China;3. School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming 650500, Yunnan, PR China;1. State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Bioactive Natural Product Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, PR China;2. Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University, 101 longmian Avenue, Nanjing 211166, PR China;1. School of Biological Science and Technology, University of Jinan, Jinan 250012, China;2. Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China;3. Shandong Provincial Engineering Research Center for Medicines of Orthopedic Pain, Shandong Mingren Freda Pharmaceutical Co., Ltd, Jinan 250104, China;1. National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;2. National Biobank of Thailand, 114 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand;3. School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People’s Republic of China;1. Programa de Pós-Graduação em Química, Universidade Federal do Amazonas, 69077–000 Manaus, AM, Brazil;2. Central Analítica - Centro de Apoio Multidisciplinar (CAM), Universidade Federal do Amazonas, 69077–000 Manaus, AM, Brazil;1. State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People’s Republic of China;2. Research Institute, Lanzhou Jiaotong University, Lanzhou 730070, People’s Republic of China |
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| Abstract: | Two new compounds named 4-(4-hydroxybenzyl)-isofraxidin (1) and 1''-methoxyl-bavacoumestan B (2), along with five known compounds (3–7) were isolated from the EtOAc-soluble extract of Abrus cantoniensis. Their structures were elucidated with spectroscopic and physico-chemical analyses. All isolates were evaluated for their cytotoxic activities against four cancer cell lines including HepG2, SMMC-7721, A549 and MCF-7. Among them, compounds 1 and 5 exhibited significant cytotoxic activity on the above four cell lines. In particular, 1 showed the potent cytotoxic activity on HepG2 and SMMC-7721 cells with IC50 values of 4.31 ± 0.5 and 3.24 ± 0.9 μM, respectively. |
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| Keywords: | Leguminosae Liver cancer Cytotoxicity |
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