| Institution: | 1. Departamento de Química Fundamental, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil;2. Department of Chemistry, Khwaja Fareed University of Engineering & Information Technology, 64200 Rahim Yar Khan, Pakistan;3. Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, Brazil;1. Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan;2. The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan;1. College of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot, 010021, China;2. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China;3. Department of Chemistry, Shanxi Medical University, Taiyuan, 030001, China;1. Children''s Hospital Affiliated of Zhengzhou University, Zhengzhou, 450000, China;2. Department of Pharmacy, Qilu Children''s Hospital of Shandong University, Jinan, 250022, China;3. Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, 210009, China |
| Abstract: | Triggered chemiluminescence emission of spiroadamantane-1,2-dioxetanes to detect bioanalytes has fueled the emerging popularity of chemiluminescence imaging in live animals and cells. Recently, a structural evolution of the dioxetane scaffolds towards near-infrared emitters has been observed, and efforts have been made for quantitative and semi-quantitative detection of a wide range of analytes. In this review, we summarize the current chemiluminescence imaging developments of spiroadamantane-1,2-dioxetanes. Specifically, we look at examples which depict whole animal or cellular chemiluminescence imaging of small molecules and enzymes, as well as those that portray their potential diagnostic and therapeutic abilities, with an emphasis on analyte quantification and experimental parameters. |
