Recent progress in metal-based molecular probes for optical bioimaging and biosensing |
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| Institution: | 1. Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, PR China;3. Chemistry and Chemical Engineering Guangdong Laboratory, Shantou, 515031, PR China;4. Spin-X Institute, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510641, PR China;5. Guangdong-Hong Kong-Macao Joint Laboratory of Optoelectronic and Magnetic Functional Materials;1. Department of Chemistry, Center for Research and Advanced Studies (Cinvestav), Mexico City, 07350, Mexico;2. Department of Pharmacology, Center for Research and Advanced Studies (Cinvestav), Mexico City, 07350, Mexico;3. Department of Physiology, Biophysics and Neurosciences, Center for Research and Advanced Studies (Cinvestav), Mexico City, 07350, Mexico;1. Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India;2. Department of Chemical Engineering and Center for Environmental Science and Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India;1. Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 35002, PR China;2. Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland |
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| Abstract: | Biological imaging and biosensing from subcellular/cellular level to whole body have enabled non-invasive visualisation of molecular events during various biological and pathological processes, giving great contributions to the rapid and impressive advances in chemical biology, drug discovery, disease diagnosis and prognosis. Optical imaging features a series of merits, including convenience, high resolution, good sensitivity, low cost and the absence of ionizing radiation. Among different luminescent probes, metal-based molecules offer unique promise in optical bioimaging and biosensing in vitro and in vivo, arising from their small sizes, strong luminescence, large Stokes shifts, long lifetimes, high photostability and tunable toxicity. In this review, we aim to highlight the design of metal-based molecular probes from the standpoint of synthetic chemistry in the last 2 years for optical imaging, covering d-block transition metal and lanthanide complexes and multimodal imaging agents. |
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| Keywords: | Transition metals Lanthanides Molecular probe Bioimaging Biosensing |
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