Evaluation of the effectiveness of fluralaner against adult stages of Rhodnius prolixus in dogs |
| |
| Affiliation: | 1. Departamento de Salud Animal y Medicina Preventiva, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Yucatán, Mexico;2. Centro de Investigaciones Regionales “Dr Hideyo Noguchi”, Universidad Autónoma de Yucatán, Mexico;3. Hospital Universitario para Perros y Gatos, Universidad Autónoma de Yucatán, Mexico;1. Institute of Parasitology, Slovak Academy of Sciences, Hlinkova 3, 040 01 Košice, Slovakia;2. Small Animal Clinic, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 040 01 Košice, Slovakia;3. Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Dúbravská cesta 9, 845 05 Bratislava, Slovakia;4. State Veterinary and Food Institute, Veterinary and Food Institute in Bratislava, Botanická 15, 842 52 Bratislava, Slovakia;5. Veterinary Hospital Marfilvet, Hodonínska 16, 841 03 Bratislava, Slovakia;6. Private Veterinary Practice Zverland, Radlinského 37, 921 01 Piešťany, Slovakia;7. Commenius University, Faculty of Natural Sciences, Bratislava, Ilkovičova 6, 842 15 Bratislava, Slovakia;1. Medical School, University of Western Australia, Perth, Western Australia, Australia;2. Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia;3. Curtin Medical School, Curtin University, Perth, Western Australia, Australia;4. Curtin Health Innovation Research Institute, Curtin University, Perth, Western Australia, Australia;1. College of the Environment & Ecology, Xiamen University, 361102 Xiamen, Fujian Province, PR China;2. Key Laboratory of Molecular Cell Biology, Ministry of Education of the People''s Republic of China; Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province; College of Life Sciences, Hebei Normal University, 050024 Shijiazhuang, Hebei Province, PR China;3. Key Laboratory of Food Safety Risk Assessment, National Health Commission of the People''s Republic of China, China National Center for Food Safety Risk Assessment (CFSA), 100021 Beijing, PR China;1. Unit of Parasitic Diseases, Department of Animal Preventive Medicine, Faculty of Veterinary Medicine, University of Chile, Santiago, Chile;2. Unit of Parasitology, Faculty of Medicine, University of Chile, Santiago, Chile;3. Small Animal Veterinary Hospital, Faculty of Veterinary Medicine, University of Chile, Santiago, Chile;4. Department of Parasitology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan;5. Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan |
| |
| Abstract: | Triatomines are vectors of American Trypanosomiasis also known as Chagas´ disease where several reservoirs including dogs are involved in the transmission cycle of the causal agent (Trypanosoma cruzi). Considering that the prevalence of American trypanosomiasis in dogs is higher than in humans and that dogs in addition are susceptible of this disease, and are involved in peridomestic transmission to humans, the search for new alternatives for vector control of the triatomines responsible for transmission in dogs is required. Over the 20 weeks the study lasted, 600 individual female, adult of Rhodnius prolixus were offered to the 15 dogs treated with a single oral dose of Fluralaner (Bravecto®, MSD). Feeding pattern of triatomines was not affected by the treatment during the whole study. The fluralaner-induced mortality of R. prolixus had a significant effect until week 12 at which time 100% mortality was observed. Mortality decreased to 67.5% at week 16 to practically nil 0.8% on week 20. Fluralaner achieved 100% mortality of triatomines between 12- and 48-h post-feeding. It was demonstrated that a single oral dose of fluralaner in dogs is highly effective in producing mortality in adult R. prolixus for the time guaranteed by the manufacturer for other blood-sucking insects, with a considerable effective residual effect for up to 16 weeks. Due to this high efficacy, fluralaner could be considered in strategies to control the transmission vectors of Chagas disease in dogs and in turn decrease the peri-domestic transmission cycle, particularly in hyperendemic areas. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
