A prospective cohort study of physical activity in relation to lung cancer incidence among Black women |
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| Affiliation: | 1. HCA Florida Brandon Hospital Department of Internal Medicine, 119 Oakfield Drive, Brandon, FL 33511, USA;2. University of Kansas School of Medicine Department of Population Health, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA;3. University of Kansas Cancer Center, 4000 Cambridge Street, Kansas City, KS 66160, USA;1. Department of Urology, New York University Grossman School of Medicine, New York, NY, United States;2. Department of Urology, SUNY Downstate Health Sciences Campus, Brooklyn, NY, United States;3. Department of Population Health, New York University Grossman School of Medicine, New York, NY, United States;4. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States;5. Department of Urology, University of North Carolina, Chapel Hill, NC, United States;6. VA NY Harbor Healthcare System, United States;7. Department of Surgery, Urology Service; Memorial Sloan Kettering Cancer Center;7. Pediatric Hematology-Oncology Unit, 1st Department of Pediatrics, ''A. Sofia'' Children''s Hospital, Athens, Greece;8. Department of Pediatric Hematology-Oncology, "Agia Sofia" Children''s Hospital, Athens, Greece;9. Department of Pediatric Hematology and Oncology, Hippokration Hospital, Thessaloniki, Greece;10. Hematology-Oncology Unit, 2nd Pediatric Department, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece;11. Department of Pediatric Hematology-Oncology, University of Crete, University Hospital of Heraklion, Heraklion, Greece;12. Department of Pediatric and Adolescent Hematology-Oncology ''Mitera'' Children''s Hospital, Athens, Greece;13. Department of Pathology, Children''s Hospital "Agia Sofia", Athens, Greece;14. Pathology Laboratory, "P & A Kyriakou" Children''s Hospital, Athens, Greece;15. Department of Paediatric Radiology (CT & MRI) and Nuclear Medicine, ''Aghia Sophia'' Children''s Hospital, Athens, Greece;p. Children''s & Adolescents Radiotherapy Department - Athens General Children''s Hospital "P. & A. Kyriakou", Athens, Greece;1. Hellenic Society for Social Pediatrics and Health Promotion, Athens, Greece;2. Department of Pediatric Hematology-Oncology, "P&A Kyriakou" Children''s Hospital, Athens, Greece;3. Department of Hygiene and Epidemiology, School of Medicine, University of Ioannina, Ioannina, Greece;4. Center for Evidence Synthesis in Health, Brown University School of Public Health, Providence, RI, USA;5. Section of Cancer Surveillance, International Agency for Research on Cancer (IARC), Lyon, France;6. Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece |
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| Abstract: | BackgroundBlack women have higher lung cancer incidence and mortality rates despite a lower smoking prevalence than White women. Physical activity may reduce lung cancer risk through several pathways, including the immune and inflammatory systems, as well as those with effects on sex hormones and metabolism.MethodsWe examined vigorous physical activity, walking for exercise, sitting watching television, and metabolic equivalents (METs) in relation to lung cancer risk among 38,432 participants in a prospective cohort of Black women. We used Cox proportional hazards models adjusted for covariates to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsIn 1995–2017, 475 incident lung cancer cases accrued. Participants who engaged in ≥ 1 h/week of vigorous physical activity or expended the highest tertile of METs experienced a decreased risk of lung cancer (HR: 0.85, 95% CI: 0.65–1.10; 0.89, 0.68–1.18; respectively). An increased risk was observed for sitting watching television (≥1 h/week: 1.27, 0.72–2.21). In stratified models, an inverse association between walking for exercise and lung cancer risk was only present among former smokers (≥1 h/week: 0.71, 0.52–0.98), while inverse associations between vigorous physical activity (≥1 h/week: 0.45, 0.28–0.73) and METs (tertile 3: 0.54, 0.34–0.85) and lung cancer risk were present among smokers with ≥ 20 pack-years.ConclusionPhysical activity may play a role in reducing lung cancer risk among Black women, particularly among smokers. Future studies should explore biologic mechanisms whereby physical activity may influence carcinogenesis and investigate the role of exercise interventions in reducing lung cancer risk among smokers. |
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| Keywords: | Exercise Metabolic equivalent Lung neoplasms African Americans Smokers |
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