降血压乳酸菌发酵乳对原发性高血压大鼠的降压效果

目的对具有血管紧张素转化酶(ACE)抑制活性的乳酸菌DM9057发酵乳的抗胃肠道酶解能力及原发性高血压大鼠(SHR)体内降压效果进行研究。方法以10 ml/kg和2.5 ml/kg发酵乳一次性和连续灌胃原发性高血压大鼠。结果 DM9057发酵乳具有较好的抗胃肠道酶能力,并且2个剂量均具有较好的降血压效果,其中以10 ml/kg剂量效果最为显著,一次性和连续灌胃后,最大降压值为(17.97±3.82)、(25.46±5.06)mmHg。结论乳酸菌DM9057发酵乳具有较强的抗胃肠道能力,同时在原发性高血压大鼠体内能够发挥一定的降血压作用。

Antihypertensive effects of fermented milk in spontaneously hypertensive rats

Objective To study the sensitiveness of fermented milk with ACE inhibitory activity on gastrointestinal enzymes.Method The fermented milk were orally administered to spontaneously hypertensive rats（SHRs） for single and twenty-eight days in 10 ml/kg and 2.5 ml/kg dosage respectively.Results The fermented milk showed the ability to resist gastrointestinal enzymes.Both dosages turned out to have satisfactory antihypertensive effect,especially the 10 ml/kg dosage which lowered the blood pressure by a maximum of（17.97±3.82） mmHg after single administration of the fermented milk and a maximum of（25.46±5.06） mmHg after continuous administration for 23 days.Conclusion Lactic acid bacteria DM9057 fermented milk has strong inhibitory activity against gastrointestinal enzymes,and plays a role in lowering the blood pressure in SHRs.