便秘型肠易激综合征患者血清神经肽Y、P物质和5-羟色胺水平与焦虑抑郁的相关性

为探讨便秘型肠易激综合征(constipation-predominant irritable bowel syndrome, C-IBS)患者血清神经肽Y (neuropeptide Y, NPY)、P物质(substance P, SP)以及5-羟色胺(5-hydroxytryptamine, 5-HT)水平与焦虑抑郁的相关性,本研究选取确诊为C-IBS的患者35例,健康对照组35例,采用焦虑自评表(self-rating anxiety scale, SAS)和抑郁自评表(self-rating depression scale, SDS)评定C-IBS患者和健康对照组的焦虑和抑郁状况。酶联免疫吸附法(enzyme-linked immunosorbent assay, ELISA)检测C-IBS患者和健康对照组血清NPY、SP以及5-羟色胺含量变化。结果表明,IBS-C中出现抑郁、焦虑或者无抑郁、焦虑的患者在各方面(性别,年龄以及病程)无统计学意义。与健康对照组相比,C-IBS组NPY和SP水平显著降低(t=7.96, p<0.01; t=5.63, p<0.01),5-HT则表现出显著性升高(t=8.06, p<0.001)。C-IBS组SAS和SDS评分结果与健康对照组相比有着显著性的升高(t=12.13, p<0.001; t=11.34, p<0.001)。C-IBS患者血清NPY与SAS和SDS评分均呈负相关(r=-0.62, p<0.001; r=-0.69, p<0.001)。C-IBS患者血清SP水平与SAS和SDS评分均呈负相关(r=-0.63, p<0.001; r=-0.57, p<0.001)。C-IBS患者血清5-HT与SAS和SDS评分均呈正相关(r=0.74, p<0.001; r=0.68, p<0.001)。本研究初步表明,C-IBS患者血清中NPY和SP水平降低,并与焦虑、抑郁评分呈负相关性,5-HT在C-IBS患者血清中升高,与焦虑、抑郁评分呈正相关性,NPY、SP以及5-HT可能在便秘型肠易激综合征出现焦虑、抑郁的过程中发挥重要作用。

Correlation between Levels of Neuropeptide Y,Substance P and 5-hydroxytryptamine with Anxiety and Depression in Patients with Constipation-predominant Irritable Bowel Syndrome

In order to investigate the correlation between levels of serum neuropeptide Y(NPY),substance P(SP),5-hydroxytryptamine(5-HT)and depression and anxiety in patients with constipation-predominant irritable bowel syndrome(C-IBS),35 patients diagnosed as C-IBS and 35 healthycontrols were selected in this research.Self-rating anxiety scale(SAS)and self-rating depression scale(SDS)were used to evaluate the anxiety and depression circu-mstance of C-IBS patients and controls.The content of serum NPY,SP and 5-HT in C-IBS patients and healthy controls were detected by enzyme-linked immunosorbent assay(ELISA).The results showed that there was no statistical significance of gender,age,and duration between C-IBS patients with depression,anxiety and C-IBS patients without depression,anxiety.Compared with the healthy control group,the levels of NPY and SP in the C-IBS group were significantly decreased(t=7.96,p<0.01;t=5.63,p<0.01),and serotonin(5-HT)was significantly increased(t=8.06,p<0.001).The scores of SAS and SDS in C-IBS group were significantly higher than those in healthy control group(t=12.13,p<0.001;t=11.34,p<0.001).The serum level of NPY in C-IBS patients was negatively correlated with SAS and SDS scores(r=-0.62,p<0.001;r=-0.69,p<0.001).The serum level of SP in C-IBS patients was negatively correlated with SAS and SDS scores(r=-0.63,p<0.001;r=-0.57,p<0.001).The serum 5-HT level in C-IBS patients was positively correlated with SAS and SDS scores(r=0.74,p<0.001;r=0.68,p<0.001).This study initially showed that the serum levels of NPY and SP in C-IBS patients were decreased and negatively correlated with anxiety and depression scores.The serum level of 5-HT in C-IBS patients was increased and positively correlated with anxiety and depression scores.NPY,SP and 5-HT might play an important role in the pathologic process of C-IBS with anxiety and depression.