| PI3K/Akt信号通路相关的生物学调控机制研究进展 |
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| 引用本文： | 钟佳琳,郑立,贺花,王健,何盼,宋成创,徐天扬,张禹,曹修凯,雷初朝,陈宏,黄永震. PI3K/Akt信号通路相关的生物学调控机制研究进展[J]. 基因组学与应用生物学, 2019, 0(1): 143-147 |
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| 作者姓名： | 钟佳琳 郑立 贺花 王健 何盼 宋成创 徐天扬 张禹 曹修凯 雷初朝 陈宏 黄永震 |
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| 作者单位： | 西北农林科技大学动物科技学院;河南牧业经济学院动物科技学院;西北农林科技大学动物医学学院 |
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| 基金项目： | 国家自然科学基金青年科学基金项目(31601926);陕西省自然科学基础研究计划面上项目(2017JM3024;2017JM3012);国家肉牛牦牛产业技术体系专项(CARS-37);河南省科技开放合作项目(172106000041);西北农林科技大学2017年大学生创新创业训练计划(S201710712152;S201710712086)共同资助 |
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| 摘 要： | PI3K/Akt信号通路是由酶联受体介导的信号转导通路,该通路不仅参与多种生长因子、细胞因子和细胞外基质等的信号转导,同时还参与细胞增殖、分化、凋亡和葡萄糖转运等多种细胞功能的调节,特别是在细胞凋亡、细胞存活以及调控细胞糖代谢等方面具有重要作用。本研究综述了PI3K-Akt信号通路的结构组成、通路活化、通信过程、调控机制及其生物学功能等方面的研究进展,为进一步研究PI3K/Akt信号通路的生物学调控作用机制提供启示。
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| 关 键 词： | PI3K/AKT信号通路 表观调节 细胞增殖 细胞分化 细胞凋亡 |
Research Progress of Biological Regulatory Mechanism Related to PI3K/Akt Signal Pathway |
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| Zhong Jialin,Zheng Li,He Hua,Wang Jian,He Pan,Song Chengchuang,Xu Tianyang,Zhang Yu,Cao Xiukai,Lei Chuchao,Chen Hong,Huang Yongzhen. Research Progress of Biological Regulatory Mechanism Related to PI3K/Akt Signal Pathway[J]. Genomics and Applied Biology, 2019, 0(1): 143-147 |
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| Authors: | Zhong Jialin Zheng Li He Hua Wang Jian He Pan Song Chengchuang Xu Tianyang Zhang Yu Cao Xiukai Lei Chuchao Chen Hong Huang Yongzhen |
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| Affiliation: | (College of Animal Science and Technology,Northwest Agriculture and Forestry University,Yangling,712100;College of Animal Science and Technology,Henan University of Animal Husbandry and Economy,Zhengzhou,450046;College of Veterinary Medicine,Northwest Agriculture and Forestry University,Yangling,712100) |
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| Abstract: | PI3K/Akt signal pathway is a signal transduction pathway mediated by enzyme-linked receptor, which not only participates in signal transduction of various growth factors, cytokines and extracellular matrix, but also participates in the regulation of cell proliferation, differentiation, apoptosis, glucose transport and other cell functions.In particular, it plays an important role in cell apoptosis, cell survival, and regulation of cell sugar metabolism. This paper reviewed the research progress of PI3K/Akt signal pathway on the structure composition, pathway activation,communication process, regulatory mechanism and biological function, and provided suggestions for the further study on the mechanism of biological regulation of PI3K/Akt signaling pathway. |
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| Keywords: | PI3K/Akt signaling pathway Epigenetic regulation Cell proliferation Cell differentiation Apoptosis |
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