Purine nucleoside phosphorylase polymorphism in sheep erythrocytes |
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Authors: | P. G. Board J. E. Smith |
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Affiliation: | (1) Department of Pathology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas |
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Abstract: | A polymorphism of purine nucleoside phosphorylase is described in sheep erythrocytes. Two isozymes were distinguished electrophoretically, one with high activity (NP-1) and one with low activity (NP-2). Breeding data suggest that the two isozymes are the product of two codominant alleles, NP1and NP2. The Km's for inosine did not differ between NP-1 and NP-2; however, NP-2 had a lower pH optimum and was relatively unstable when incubated at 48 C.Contribution No. 421-J, from the Department of Pathology, Kansas Agricultural Experiment Station, Manhattan, Kansas. Supported in part by USPHS Grants HL-70119 and HL 12072. |
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Keywords: | purine nucleoside phosphorylase polymorphism erythrocyte sheep |
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