Interaction of subtilisin BPN' and recombinant fungal protease inhibitor F from silkworm with substituted P1 site residues |
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| Authors: | Taniguchi Mai Atiwetin Panida Hirai Tomoya Itoh Masanobu Harada Shigeharu Hara Saburo Kamei Kaeko |
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| Institution: | Department of Applied Biology, Kyoto Institute of Technology, Japan. |
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| Abstract: | Fungal protease inhibitor F (FPI-F) from silkworm inhibits subtilisin and fungal proteases. FPI-F mutants P(1) residues of which, Thr(29), were replaced with Glu, Phe, Gly, Leu, Met, and Arg, were prepared. The inhibitory activities of mutated FPI-F against subtilisin and other mammalian proteases indicated that FPI-F might be a specific inhibitor toward subtilisin-type protease. |
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