Ganglioside GD3: structure,cellular distribution,and possible function |
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Authors: | Thomas N Seyfrieda Robert K Yu |
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Institution: | (1) Department of Neurology, Yale University School of Medicine, 333 Cedar Street, 06510 New Haven, Connecticut, USA;(2) Present address: Department of Biology, Boston College, 02167 Chestnut Hill, Massachusetts, USA;(3) Department of Biology, Boston College, 02167 Chestnut Hill, Massachusetts, USA |
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Abstract: | Summary Insight on the function of gangliosides. can emerge from knowledge of their cellular distribution. In this paper we review the structure of ganglioside GD3 and recent information on its cellular distribution. GD3 appears to be enriched in a variety of neural cell types including: reactive glia, gliomas, undifferentiated neurons, Muller glia, and oligodendroglia. Because each of these cell types share an enhanced permeability to ions and metabolites or possess properties associated with enhanced permeability, we suggest that GD3 is associated with enhanced membrane permeability. A possible function for GD3 in membrane permeability has implications for other cellular events such as metabolism, growth and interactions. |
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Keywords: | gangliosides reactive glia gliomas development mutant mice membrane permeability |
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