Antioxidant effect of selenium on lipid peroxidation,hyperlipidemia and biochemical parameters in rats exposed to diazinon |
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| Affiliation: | 1. Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt;2. Department of Pest Control and Environmental Protection, Faculty of Agriculture, Damanhour University, Damanhour, Egypt;1. Department of Cardiovascular Medicine, Faculty of Medicine, Ain Shams University, Cairo;1. Food Science Technology College of Henan Agricultural University, Zhengzhou 450002, China;2. College of Public Health, Zhengzhou University, Zhengzhou 450001, China;1. State Key Laboratory of Food Science and Technology, Nanchang University, Jiangxi 330047, China;2. Jiangxi Academy of Sciences, Jiangxi 330029, China;3. Department of Chemical Engineering, Monash University, Clayton, Victoria 3800, Australia;1. Department of Cardiology, Gulhane Medical Faculty, Ankara, aTurkey;2. Department of Cardiology, Ankara Mevki Military Hospital, Ankara, bTurkey;1. National Poison Centre, Universiti Sains Malaysia, 11800, USM, Penang, Malaysia;2. Malaysian Institute of Pharmaceuticals and Nutraceuticals (IPharm), National Institutes of Biotechnology Malaysia, Ministry of Science, Technology and Innovation, Block 5-D, Halaman Bukit Gambir, 11700 Penang, Malaysia;1. University of Dammam, Internal Medicine/Cardiology King Fahad Hospital of the University, PO Box 12875, Dammam 31483, Saudi Arabia |
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| Abstract: | Diazinon (DZN) is one of the most organophosphate insecticides that widely used in agriculture and industry. Selenium is generally recognized to be a trace mineral of great importance for human health, protecting the cells from the harmful effects of free radicals. Therefore, the present study was carried out to investigate the alterations in biochemical parameters, free radicals and enzyme activities induced by diazinon in male rat serum, and the role of selenium in alleviating the negative effects of DZN. Animals were divided into four groups of seven rats each; the first group was used as control. Groups 2, 3 and 4 were treated with selenium (Se; 200 μg/kg BW), diazinon (DZN; 10 mg/kg BW) and diazinon plus selenium, respectively. Rats were orally administered their respective doses daily for 30 days. Results obtained showed that DZN significantly induced thiobarbituric acid reactive substances (TBARS) and decreased the activities of glutathione S-transferase (GST), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) and the levels of reduced glutathione (GSH) in rat sera. Aminotransferases (AST, ALT), phosphatases (AlP, AcP) and lactate dehydrogenase (LDH) activities were significantly increased while acetylcholinesterase (AChE) activity was decreased due to DZN administration. Also, DZN treatment caused significant perturbations in lipids profile and serum biochemical parameters. On the other hand, Se alone significantly decreased the levels of TBARS, total lipids, cholesterol, urea and creatinine, while increased the activities of antioxidant enzymes and glutathione content, total protein (TP) and albumin. In addition, Se in combination with DZN partially or totally alleviated its toxic effects on the studied parameters. In conclusion, Se has beneficial effects and could be able to antagonize DZN toxicity. |
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| Keywords: | Diazinon Selenium Enzymes Oxidative stress Lipids profile |
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