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Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus
Affiliation:1. State Key Laboratory of Chirosciences, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China;2. Centre of Biotechnology, Department of Life Sciences and Biotechnology, The University of Ferrara, Ferrara, Italy;3. School of Biomedical Sciences and Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China;4. Department of Chemistry, Guangzhou University, Guangzhou, People’s Republic of China;5. Institute of Creativity, Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, China;6. Clinical Division, School of Chinese Medicine, Hong Kong Baptist University, Waterloo Road, Kowloon Tong, Hong Kong, China;1. Research Institute of Pesticidal Design & Synthesis, College of Sciences, Northwest A&F University, Yangling 712100, Shaanxi Province, People’s Republic of China;2. State Key Laboratory of Crop Stress Biology for Arid Areas, Northwest A&F University, Yangling 712100, Shaanxi Province, People’s Republic of China;1. Department of Organic Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar 47416-95447, Iran;2. Nano and Biotechnology Research Group, University of Mazandaran, Babolsar 47416-95447, Iran;3. Department of Microbiology, Faculty of Sciences, University of Mazandaran, Babolsar 47416-95447, Iran;1. Department of Inorganic Chemistry, Institute of Chemistry, P. J. Šafárik University in Košice, Moyzesova 11, 040 01 Košice, Slovakia;2. Center of Molecular Medicine and Stem Cell Research, Faculty of Medical Sciences, University of Kragujevac, S. Markovica 69, 34000 Kragujevac, Serbia;3. Insitute of Microbiology and Immunology, School of Medicine, University of Belgrade, Dr. Subotica 8, 11000 Belgrade, Serbia;4. Department of Biology and Ecology, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia;5. Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia;6. Institute of Geotechnics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia;1. Department of Safety Evaluation, Technology Center of China Tobacco Yunnan Industrial Co., Ltd., Kunming 650106, China;2. College of Chemical Science and Technology, Yunnan University, Kunming 650091, China;3. College of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China;1. Departamento de Química, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil;2. Departamento de Fisiologia, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil;3. Universidad Nacional de La Plata, C. Correo 962, 1900 La Plata, Argentina;1. Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Professor Gama Pinto, 1649-003 Lisbon, Portugal;2. INSA, National Health Institute Dr. Ricardo Jorge, Avenida Padre Cruz, 1649-016 Lisbon, Portugal
Abstract:This work describes the preparation of quinoline compounds as possible anti-bacterial agents. The synthesized quinoline derivatives show anti-bacterial activity towards Staphylococcus aureus. It is interesting to observe that the synthetic 5,7-dibromo-2-methylquinolin-8-ol (4) shows a similar minimum inhibitory concentration of 6.25 μg/mL as compared to that of methicillin (3.125 μg/mL) against Staphylococcus aureus.
Keywords:Antibacterial agents  Antibiotics  Quinolines
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